结直肠癌信号通路对靶向疗法的影响。

IF 6.3 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular biomedicine Pub Date : 2024-06-07 DOI:10.1186/s43556-024-00178-y
Yanlin Song, Ming Chen, Yuhao Wei, Xuelei Ma, Huashan Shi
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引用次数: 0

摘要

结直肠癌(CRC)是一个紧迫的全球性健康问题,其特点是未成熟细胞在多方面内外因素的影响下肆意增殖。大量研究探索了 CRC 肿瘤发生的复杂机制,主要重点是信号通路,尤其是与生长因子和趋化因子相关的信号通路。然而,分子靶点的多样性给靶向疗法的选择带来了复杂性,给实现精准治疗带来了巨大挑战。由于缺乏对肿瘤细胞突变或改变的病理学洞察,寻找有效的 CRC 治疗方法变得更加复杂。这项研究揭示了从细胞膜到细胞核的信号传递,揭示了这一关键细胞过程的最新进展。通过揭示这一新颖的层面,研究加深了我们对 CRC 潜在的分子复杂性的理解,为靶向治疗策略的突破提供了潜在的途径。此外,该研究还全面概述了信号通路异常激活所引发的潜在免疫反应,重点关注免疫细胞、细胞因子及其对药物开发动态格局的集体影响。这项研究不仅极大地推动了结直肠癌治疗和分子医学的发展,还为未来的突破和临床试验奠定了基础,为改善结直肠癌的治疗效果和改进治疗方法带来了希望。
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Signaling pathways in colorectal cancer implications for the target therapies.

Colorectal carcinoma (CRC) stands as a pressing global health issue, marked by the unbridled proliferation of immature cells influenced by multifaceted internal and external factors. Numerous studies have explored the intricate mechanisms of tumorigenesis in CRC, with a primary emphasis on signaling pathways, particularly those associated with growth factors and chemokines. However, the sheer diversity of molecular targets introduces complexity into the selection of targeted therapies, posing a significant challenge in achieving treatment precision. The quest for an effective CRC treatment is further complicated by the absence of pathological insights into the mutations or alterations occurring in tumor cells. This study reveals the transfer of signaling from the cell membrane to the nucleus, unveiling recent advancements in this crucial cellular process. By shedding light on this novel dimension, the research enhances our understanding of the molecular intricacies underlying CRC, providing a potential avenue for breakthroughs in targeted therapeutic strategies. In addition, the study comprehensively outlines the potential immune responses incited by the aberrant activation of signaling pathways, with a specific focus on immune cells, cytokines, and their collective impact on the dynamic landscape of drug development. This research not only contributes significantly to advancing CRC treatment and molecular medicine but also lays the groundwork for future breakthroughs and clinical trials, fostering optimism for improved outcomes and refined approaches in combating colorectal carcinoma.

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CiteScore
6.30
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审稿时长
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