人工智能驱动的 Q-learning 个性化痤疮遗传学:创新方法和潜在遗传标记

IF 5 3区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Egyptian Informatics Journal Pub Date : 2024-06-01 DOI:10.1016/j.eij.2024.100484
Yong Chi Chua , Hui Wen Nies , Izyan Izzati Kamsani , Haslina Hashim , Yusliza Yusoff , Weng Howe Chan , Muhammad Akmal Remli , Yong Hui Nies , Mohd Saberi Mohamad
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引用次数: 0

摘要

目前正在研究痤疮的遗传标记,以便根据个人基因创造个性化治疗方法,而人工智能(AI)技术的应用正使这一领域受益匪浅。其中一种人工智能工具--Q-learning 算法,正越来越多地被医学研究人员用来研究痤疮的遗传学。与以往的方法不同,我们的研究引入了一种Q-learning模型,可适应不同的样本群体。这种创新方法包括通过识别差异表达基因和构建基因-基因连接网络对数据进行预处理。使用 Q-learning 模型的主要优势在于它能将尖锐的基因数据转化为马尔可夫域,而马尔可夫域对于选择相关遗传标记至关重要。对我们的 Q-learning 模型进行的性能评估显示,尽管灵敏度可能存在一些差异,但准确性和特异性都很高。值得注意的是,这项研究通过生物验证和文本数据挖掘,确定了与痤疮相关的特定基因,如 CD86、AGPAT3、TMPRSS11D、DSG3、TNFRSF1B、PI3、C5AR1 和 KRT16。这些发现凸显了人工智能驱动的Q-learning模型在革新痤疮遗传学研究方面的潜力。总之,我们的 Q-learning 模型为痤疮相关遗传标记的筛选提供了一种很有前景的方法,尽管灵敏度会有轻微波动。这项研究凸显了 Q-learning 在促进我们对痤疮遗传学的理解方面所具有的变革潜力,为未来更个性化、更有效的治疗铺平了道路。
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AI-driven Q-learning for personalized acne genetics: Innovative approaches and potential genetic markers

Genetic markers for acne are being studied to create personalized treatments based on an individual’s genes, and the field is benefiting from the application of artificial intelligence (AI) techniques. One such AI tool, the Q-learning algorithm, is increasingly being utilized by medical researchers to delve into the genetics of acne. In contrast to previous methods, our research introduces a Q-learning model that is adaptable to diverse sample groups. This innovative approach involves preprocessing data by identifying differentially expressed genes and constructing gene-gene connectivity networks. The key advantage of using the Q-learning model lies in its ability to transform acne gene data into Markovian domains, which are essential for selecting relevant genetic markers. Performance evaluations of our Q-learning model have shown high accuracy and specificity, although there may be some sensitivity variations. Notably, this research has identified specific genes, such as CD86, AGPAT3, TMPRSS11D, DSG3, TNFRSF1B, PI3, C5AR1, and KRT16, as being acne-related through biological verification and text data mining. These findings underscore the potential of AI-driven Q-learning models to revolutionize the study of acne genetics. In conclusion, our Q-learning model offers a promising approach for the selection of acne-related genetic markers, despite minor sensitivity fluctuations. This research highlights the transformative potential of Q-learning in advancing our understanding of the genetics underlying acne, paving the way for more personalized and effective treatments in the future.

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来源期刊
Egyptian Informatics Journal
Egyptian Informatics Journal Decision Sciences-Management Science and Operations Research
CiteScore
11.10
自引率
1.90%
发文量
59
审稿时长
110 days
期刊介绍: The Egyptian Informatics Journal is published by the Faculty of Computers and Artificial Intelligence, Cairo University. This Journal provides a forum for the state-of-the-art research and development in the fields of computing, including computer sciences, information technologies, information systems, operations research and decision support. Innovative and not-previously-published work in subjects covered by the Journal is encouraged to be submitted, whether from academic, research or commercial sources.
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