糖酵解在肿瘤中的调节作用和临床意义。

IF 20.1 1区 医学 Q1 ONCOLOGY Cancer Communications Pub Date : 2024-06-08 DOI:10.1002/cac2.12549
Qiqi Qiao, Shunfeng Hu, Xin Wang
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引用次数: 0

摘要

代谢重编程已被证明对肿瘤细胞的生物学行为有重大影响,而糖酵解是其中的一种重要形式。最新研究发现,糖酵解水平的升高、糖酵解酶的异常表达以及糖酵解产物的积累可调控肿瘤细胞的生长、增殖、侵袭和转移,并为肿瘤的发生和发展提供有利的微环境。基于肿瘤细胞独特的糖酵解特性,人们开发了新型成像检测方法来评估肿瘤的增殖和转移。此外,人们还发现糖酵解酶可作为肿瘤的生物标记物,有助于肿瘤患者的早期诊断和预后评估。许多糖酵解酶已被确定为治疗肿瘤的潜在靶点,针对糖酵解酶的各种小分子抑制剂已被开发出来以抑制肿瘤的发展,其中一些已应用于临床。在这篇综述中,我们系统地总结了糖酵解在肿瘤进展中的调控作用的最新进展,并强调了糖酵解酶及其产物作为新型生物标记物和治疗靶点在肿瘤治疗中的潜在临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The regulatory roles and clinical significance of glycolysis in tumor

Metabolic reprogramming has been demonstrated to have a significant impact on the biological behaviors of tumor cells, among which glycolysis is an important form. Recent research has revealed that the heightened glycolysis levels, the abnormal expression of glycolytic enzymes, and the accumulation of glycolytic products could regulate the growth, proliferation, invasion, and metastasis of tumor cells and provide a favorable microenvironment for tumor development and progression. Based on the distinctive glycolytic characteristics of tumor cells, novel imaging tests have been developed to evaluate tumor proliferation and metastasis. In addition, glycolytic enzymes have been found to serve as promising biomarkers in tumor, which could provide assistance in the early diagnosis and prognostic assessment of tumor patients. Numerous glycolytic enzymes have been identified as potential therapeutic targets for tumor treatment, and various small molecule inhibitors targeting glycolytic enzymes have been developed to inhibit tumor development and some of them are already applied in the clinic. In this review, we systematically summarized recent advances of the regulatory roles of glycolysis in tumor progression and highlighted the potential clinical significance of glycolytic enzymes and products as novel biomarkers and therapeutic targets in tumor treatment.

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来源期刊
Cancer Communications
Cancer Communications Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
25.50
自引率
4.30%
发文量
153
审稿时长
4 weeks
期刊介绍: Cancer Communications is an open access, peer-reviewed online journal that encompasses basic, clinical, and translational cancer research. The journal welcomes submissions concerning clinical trials, epidemiology, molecular and cellular biology, and genetics.
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