0.1% 聚己内酯和丙基甜菜碱在急性和难愈合伤口上的临床应用:文献综述。

IF 1.5 4区 医学 Q3 DERMATOLOGY Journal of wound care Pub Date : 2024-06-01 DOI:10.12968/jowc.2019.0066
Giuseppe Lazzari, Simonetta Cesa, Emilia Lo Palo
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引用次数: 0

摘要

目的总结临床使用 0.1% 聚己内酯-丙基甜菜碱(PHMB/甜菜碱)溶液/凝胶对急性和难愈合(慢性)伤口愈合的影响:在 MEDLINE、CINAHL、Embase、Scopus 和 Cochrane 协作组织的 CENTRAL 试验注册中心进行文献检索。配对审稿人进行了标题和摘要筛选以及全文筛选,以确定实验性、准实验性和观察性研究。未对研究质量和偏倚风险进行正式评估:共有 17 项研究符合资格标准。12项研究结果表明,使用0.1% PHMB/甜菜碱溶液/凝胶具有以下优点:接触性敏感风险低;在清洗伤口时有助于清创;有助于有效的伤口床准备;减少伤口面积、气味和渗出物;改善疼痛控制;减少微生物负荷;促进伤口愈合。三项研究结果表明,0.1% PHMB 和生理盐水都能有效减少细菌量,而另一项研究表明,在扎带式敷料中添加 0.1% PHMB 对减少伤口细菌量没有效果。另一项研究认为,与使用 0.1% PHMB/甜菜碱相比,使用含 0.3% PHMB 的水平衡敷料对压疮进行消毒和肉芽化更快更有效:本次文献综述的结果表明,0.1% PHMB/甜菜碱溶液/凝胶似乎对伤口清洁有用且安全,能有效清除伤口床上的软屑和痂皮,并为伤口愈合创造最佳环境。虽然这些作用不能完全归功于这种治疗方式,但这些结果确实凸显了这种组合产品的独特作用。不过,还需要更多的研究来证实这些结果。
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Clinical use of 0.1% polyhexanide and propylbetaine on acute and hard-to-heal wounds: a literature review.

Objective: To summarise the findings on the effect of the clinical use of 0.1% polyhexanide-propylbetaine (PHMB/betaine) solution/gel on acute and hard-to-heal (chronic) wound healing.

Method: A literature search was conducted in MEDLINE, CINAHL, Embase, Scopus and the CENTRAL Trials Registry of the Cochrane Collaboration. Paired reviewers conducted title and abstract screening and full-text screening to identify experimental, quasi-experimental and observational studies. Study quality and risk of bias were not formally evaluated.

Results: A total of 17 studies met the eligibility criteria. The findings from 12 studies indicated that the use of 0.1% PHMB/betaine solution/gel had: a low risk of contact sensitivity; could help debridement during wound cleansing; aided effective wound bed preparation; reduced wound size, odour and exudate; improved pain control; reduced microbial load; and enhanced wound healing. The results of three studies indicated that both 0.1% PHMB and saline solution were effective in reducing bacterial load, while another showed that adding 0.1% PHMB to tie-over dressings had no effect on reducing bacterial loads in wounds. Another study concluded that disinfection and granulation of pressure ulcers with hydrobalance dressing with 0.3% PHMB was faster and more effective than using 0.1% PHMB/betaine.

Conclusion: The findings of this literature review showed that 0.1% PHMB/betaine solution/gel appeared to be useful and safe for wound cleansing, was effective in removing soft debris and slough from the wound bed, and created a wound environment optimal for healing. Although these actions cannot be attributed solely to this treatment modality, these results do highlight the unique action of this combined product. However, more robust studies are needed to confirm these results.

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来源期刊
Journal of wound care
Journal of wound care DERMATOLOGY-
CiteScore
2.90
自引率
10.50%
发文量
215
期刊介绍: Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.
期刊最新文献
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