肿瘤学中的全身 PET-CT 方案。

IF 4.6 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Seminars in nuclear medicine Pub Date : 2024-06-07 DOI:10.1053/j.semnuclmed.2024.05.008
Antonia Dimitrakopoulou-Strauss, Leyun Pan, Christos Sachpekidis
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引用次数: 0

摘要

最近开发的长轴视野 PET-CT 扫描仪(包括全身扫描仪)已在全球一些中心投入使用。与标准轴向视场(SAFOV)PET-CT 扫描仪相比,这些系统具有一些主要优势,主要是灵敏度最高可提高 20 倍,从而提高了病变的可探测性。其他优势还包括:缩短了静态全身测量的 PET 采集时间,减少了放射性示踪剂的施用剂量,以及能够以良好的图像质量进行延迟扫描,这对于成像半衰期长的放射性核素和生物分布时间长的药物(如 89Zr 标记的抗体)非常重要。减少示踪剂的应用剂量可减少辐射照射,有助于进行纵向研究,尤其是对肿瘤患者的治疗评估。静态全身(WB)研究的采集时间缩短,可显著提高患者的诊疗量。此外,LAFOV PET-CT 扫描仪首次实现了 WB 动态 PET 扫描和 WB 参数成像,由于提高了灵敏度和时间分辨率,图像质量也得到了改善。WB 示踪剂动力学对于新型放射性药物的特征描述、更好地描述癌症疾病的生物学特征以及更准确地评估新靶向疗法的反应具有特别重要的意义。基于人工智能(AI)方法的进一步技术发展正在进行中,未来可能实现无 CT 衰减校正或超低剂量 CT 衰减校正,以及评估代谢肿瘤总体积的分割算法。本综述旨在介绍使用LAFOV扫描仪进行肿瘤研究的专用PET采集协议,包括静态和动态采集以及参数扫描,并介绍迄今为止有关该主题的文献数据。
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Total Body PET-CT Protocols in Oncology.

Recently developed long axial field of view (LAFOV) PET-CT scanners, including total body scanners, are already in use in a few centers worldwide. These systems have some major advantages over standard axial field of view (SAFOV) PET-CT scanners, mainly due to up to 20 times higher sensitivity and therefore improved lesion detectability. Other advantages are the reduction of the PET acquisition time for a static whole-body measurement, the reduction of the administered radiotracer dose, and the ability to perform delayed scans with good image quality, which is important for imaging radionuclides with long half-lives and pharmaceuticals with long biodistribution times, such as 89Zr-labeled antibodies. The reduction of the applied tracer dose leads to less radiation exposure and may facilitate longitudinal studies, especially in oncological patients, for the evaluation of therapy. The reduction in acquisition time for a static whole body (WB) study allows a markedly higher patient throughput. Furthermore, LAFOV PET-CT scanners enable for the first-time WB dynamic PET scanning and WB parametric imaging with an improved image quality due to increased sensitivity and time resolution. WB tracer kinetics is of particular interest for the characterization of novel radiopharmaceuticals and for a better biological characterization of cancer diseases, as well as for a more accurate assessment of the response to new targeted therapies. Further technological developments based on artificial intelligence (AI) approaches are underway and may in the future allow CT-less attenuation correction or ultralow dose CT for attenuation correction as well as segmentation algorithms for the evaluation of total metabolic tumor volume. The aim of this review is to present dedicated PET acquisition protocols for oncological studies with LAFOV scanners, including static and dynamic acquisition as well as parametric scans, and to present literature data to date on this topic.

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来源期刊
Seminars in nuclear medicine
Seminars in nuclear medicine 医学-核医学
CiteScore
9.80
自引率
6.10%
发文量
86
审稿时长
14 days
期刊介绍: Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.
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