牛皮癣转化为皮肤 t 细胞淋巴瘤的病例。

V Tkach, O Aleksandruk, І Kostyshyn, M Voloshynovych, G Girnyk, S Romanchuk
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摘要

牛皮癣是一种久负盛名的皮肤病,其发病率不断上升,但由于研究设计的差异,无法明确确定其发病趋势。近年来,儿童和青少年中的发病人数有所增加。银屑病变得更具侵袭性,严重的银屑病更为常见。牛皮癣可合并其他疾病,但很少并发。文献中已经描述了银屑病斑块转变为皮肤癌的孤立病例。可能的原因是长期使用光敏剂和光疗、萘和焦油。不过,一般来说,银屑病患者恶性肿瘤复发的风险并没有明显增加。我们介绍了一位有超过 37 年银屑病病史的患者银屑病转化为皮肤 T 细胞淋巴瘤的临床观察结果,该患者在典型银屑病皮疹的基础上出现了稠厚的真菌生长,最初被误认为是疣状银屑病。根据其他检查方法的数据和组织学检查的结果,明确了诊断。对症下药,疗效显著。我们认为,退化的可能原因是长期的刺激性外部治疗和过度日晒。
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CASE OF THE TRANSFORMATION OF PSORIASIS INTO CUTANEOUS T-CELL LYMPHOMA.

Psoriasis is a long-known skin pathology, the incidence of which is constantly rising, though it is not possible to clearly establish the trend due to the differences in the research design. In recent years, the number of cases among children and adolescents has increased. Psoriasis becomes more aggressive, severe forms are more common. It can be combined with other diseases but is rarely complicated. Isolated cases of the transformation of psoriatic plaques into skin cancer have already been described in the literature. Probable causes were the long-term use of photosensitizers and phototherapy, naphthalene, and tar. However, in general, the risk of the malignant recurrence in patients with psoriasis does not increase significantly. We present a clinical observation of the transformation of psoriasis into cutaneous T-cell lymphoma in a patient with more than 37 years of psoriasis experience, where on the background of typical psoriatic rashes, fungal growths of doughy consistency appeared, which were initially misinterpreted as a warty form of psoriasis. Based on the data of additional methods of examination and the results of histological examination, the diagnosis was clarified. Specific treatment was prescribed, which proved its effectiveness. The probable causes of degeneration, in our opinion, are prolonged irritating external therapy and excessive insolation.

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