赤痢链球菌马氏亚种感染及其与化脓性链球菌的交叉感染。

IF 19 1区 医学 Q1 MICROBIOLOGY Clinical Microbiology Reviews Pub Date : 2024-09-12 Epub Date: 2024-06-10 DOI:10.1128/cmr.00175-23
Ouli Xie, Mark R Davies, Steven Y C Tong
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引用次数: 0

摘要

摘要赤痢链球菌马氏亚种(SDSE)越来越多地被认为是人类疾病的诱因。疾病表现从非侵袭性表皮和软组织感染到危及生命的链球菌中毒性休克综合症和坏死性筋膜炎。侵袭性疾病通常与并发症、免疫抑制和年龄增长有关。侵袭性疾病的粗发病率接近与之密切相关的病原体化脓性链球菌。使用全基因组测序的基因组流行病学揭示了全球 SDSE 种群动态的重要信息,包括新出现的品系和抗微生物耐药性的传播。它还补充了对 SDSE 和化脓性链球菌之间重叠病理生物学的观察,包括共享毒力因子和移动基因内容,这可能是共享病原体表型的基础。本综述概述了人类感染 SDSE 的临床和基因组流行病学、疾病表现、治疗和毒力决定因素,尤其关注其与化脓性链球菌的重叠。在此过程中,我们强调了了解 SDSE 与化脓性链球菌重叠的重要性,以便为监测和疾病控制策略提供依据。
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Streptococcus dysgalactiae subsp. equisimilis infection and its intersection with Streptococcus pyogenes.

SUMMARYStreptococcus dysgalactiae subsp. equisimilis (SDSE) is an increasingly recognized cause of disease in humans. Disease manifestations range from non-invasive superficial skin and soft tissue infections to life-threatening streptococcal toxic shock syndrome and necrotizing fasciitis. Invasive disease is usually associated with co-morbidities, immunosuppression, and advancing age. The crude incidence of invasive disease approaches that of the closely related pathogen, Streptococcus pyogenes. Genomic epidemiology using whole-genome sequencing has revealed important insights into global SDSE population dynamics including emerging lineages and spread of anti-microbial resistance. It has also complemented observations of overlapping pathobiology between SDSE and S. pyogenes, including shared virulence factors and mobile gene content, potentially underlying shared pathogen phenotypes. This review provides an overview of the clinical and genomic epidemiology, disease manifestations, treatment, and virulence determinants of human infections with SDSE with a particular focus on its overlap with S. pyogenes. In doing so, we highlight the importance of understanding the overlap of SDSE and S. pyogenes to inform surveillance and disease control strategies.

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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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