在监测早期和晚期乳腺癌方面,ctDNA 是否已准备好超越成像技术?

IF 2.9 3区 医学 Q2 ONCOLOGY Expert Review of Anticancer Therapy Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI:10.1080/14737140.2024.2362173
Lorenzo Foffano, Riccardo Vida, Alberto Piacentini, Elisabetta Molteni, Linda Cucciniello, Lucia Da Ros, Buriolla Silvia, Lorenzo Cereser, Rossana Roncato, Lorenzo Gerratana, Fabio Puglisi
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引用次数: 0

摘要

导言:循环肿瘤 DNA(ctDNA)和放射成像越来越被认为是乳腺癌治疗的关键因素。虽然放射学仍是筛查和监测的基石,但ctDNA在预测诊断、复发或进展方面具有独特的优势,可提供与影像学结果相辅相成的生物学见解。它介绍了ctDNA在早期和晚期的临床有效性和实用性数据,提供了对新兴液体活检技术(如表观遗传学和片段组学)的见解。专家观点:目前在技术、战略和经济方面存在诸多挑战,阻碍了ctDNA分析在乳腺癌监测中的临床应用。了解这些复杂性并制定有针对性的策略,对于将这种方法有效地应用于个性化患者护理至关重要。
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Is ctDNA ready to outpace imaging in monitoring early and advanced breast cancer?

Introduction: Circulating tumor DNA (ctDNA) and radiological imaging are increasingly recognized as crucial elements in breast cancer management. While radiology remains the cornerstone for screening and monitoring, ctDNA holds distinctive advantages in anticipating diagnosis, recurrence, or progression, providing concurrent biological insights complementary to imaging results.

Areas covered: This review delves into the current evidence on the synergistic relationship between ctDNA and imaging in breast cancer. It presents data on the clinical validity and utility of ctDNA in both early and advanced settings, providing insights into emerging liquid biopsy techniques like epigenetics and fragmentomics. Simultaneously, it explores the present and future landscape of imaging methodologies, particularly focusing on radiomics.

Expert opinion: Numerous are the current technical, strategic, and economic challenges preventing the clinical integration of ctDNA analysis in the breast cancer monitoring. Understanding these complexities and devising targeted strategies is pivotal to effectively embedding this methodology into personalized patient care.

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来源期刊
CiteScore
5.10
自引率
3.00%
发文量
100
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.
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