Suhaib Js Ahmad, Jason R Degiannis, Joseph Borucki, Sjaak Pouwels, David Laith Rawaf, Anil Lala, Graham S Whiteley, Marion Head, Angharad Simpson, Rami Archid, Ahmed R Ahmed, J Agustin Soler, Doerte Wichmann, Mohanarangam Thangavelu, Mohamed Abdulmajed, Mahmoud Elmousili, Yan-Ren Lin, Edgar Gelber, Aristomenis K Exadaktylos
{"title":"感染奥密克龙变种（B.1.1.529）后的死亡率：死亡率有多高？系统回顾与元分析》。","authors":"Suhaib Js Ahmad, Jason R Degiannis, Joseph Borucki, Sjaak Pouwels, David Laith Rawaf, Anil Lala, Graham S Whiteley, Marion Head, Angharad Simpson, Rami Archid, Ahmed R Ahmed, J Agustin Soler, Doerte Wichmann, Mohanarangam Thangavelu, Mohamed Abdulmajed, Mahmoud Elmousili, Yan-Ren Lin, Edgar Gelber, Aristomenis K Exadaktylos","doi":"10.6705/j.jacme.202406_14(2).0001","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Since late 2019, the global community has been gripped by the uncertainty surrounding the SARS-CoV-2 pandemic. In November 2021, the emergence of the Omicron variant in South Africa added a new dimension. This study aims to assess the disease's severity and determine the extent to which vaccinations contribute to reducing mortality rates.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of the epidemiological implications of the omicron variant of SARS-CoV-2 were performed, incorporating an analysis of articles from November 2021that address mortality rates.</p><p><strong>Results: </strong>The analysis incorporated data from 3,214,869 patients infected with omicron, as presented in 270 articles. A total of 6,782 deaths from the virus were recorded (0.21%). In the analysed articles, the pooled mortality rate was 0.003 and the pooled in-house mortality rate was 0.036. Vaccination is an effective step in preventing death (odds ratio: 0.391, <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>The mortality rates for the omicron variant are lower than for the preceding delta variant. mRNA vaccination affords secure and effective protection against severe disease and death from omicron.</p>","PeriodicalId":14846,"journal":{"name":"Journal of acute medicine","volume":"14 2","pages":"51-60"},"PeriodicalIF":0.8000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153312/pdf/","citationCount":"0","resultStr":"{\"title\":\"Fatality Rates After Infection With the Omicron Variant (B.1.1.529): How Deadly has it been? A Systematic Review and Meta-Analysis.\",\"authors\":\"Suhaib Js Ahmad, Jason R Degiannis, Joseph Borucki, Sjaak Pouwels, David Laith Rawaf, Anil Lala, Graham S Whiteley, Marion Head, Angharad Simpson, Rami Archid, Ahmed R Ahmed, J Agustin Soler, Doerte Wichmann, Mohanarangam Thangavelu, Mohamed Abdulmajed, Mahmoud Elmousili, Yan-Ren Lin, Edgar Gelber, Aristomenis K Exadaktylos\",\"doi\":\"10.6705/j.jacme.202406_14(2).0001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Since late 2019, the global community has been gripped by the uncertainty surrounding the SARS-CoV-2 pandemic. In November 2021, the emergence of the Omicron variant in South Africa added a new dimension. This study aims to assess the disease's severity and determine the extent to which vaccinations contribute to reducing mortality rates.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of the epidemiological implications of the omicron variant of SARS-CoV-2 were performed, incorporating an analysis of articles from November 2021that address mortality rates.</p><p><strong>Results: </strong>The analysis incorporated data from 3,214,869 patients infected with omicron, as presented in 270 articles. A total of 6,782 deaths from the virus were recorded (0.21%). In the analysed articles, the pooled mortality rate was 0.003 and the pooled in-house mortality rate was 0.036. Vaccination is an effective step in preventing death (odds ratio: 0.391, <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>The mortality rates for the omicron variant are lower than for the preceding delta variant. mRNA vaccination affords secure and effective protection against severe disease and death from omicron.</p>\",\"PeriodicalId\":14846,\"journal\":{\"name\":\"Journal of acute medicine\",\"volume\":\"14 2\",\"pages\":\"51-60\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153312/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of acute medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.6705/j.jacme.202406_14(2).0001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"EMERGENCY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of acute medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6705/j.jacme.202406_14(2).0001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"EMERGENCY MEDICINE","Score":null,"Total":0}
Fatality Rates After Infection With the Omicron Variant (B.1.1.529): How Deadly has it been? A Systematic Review and Meta-Analysis.
Background: Since late 2019, the global community has been gripped by the uncertainty surrounding the SARS-CoV-2 pandemic. In November 2021, the emergence of the Omicron variant in South Africa added a new dimension. This study aims to assess the disease's severity and determine the extent to which vaccinations contribute to reducing mortality rates.
Methods: A systematic review and meta-analysis of the epidemiological implications of the omicron variant of SARS-CoV-2 were performed, incorporating an analysis of articles from November 2021that address mortality rates.
Results: The analysis incorporated data from 3,214,869 patients infected with omicron, as presented in 270 articles. A total of 6,782 deaths from the virus were recorded (0.21%). In the analysed articles, the pooled mortality rate was 0.003 and the pooled in-house mortality rate was 0.036. Vaccination is an effective step in preventing death (odds ratio: 0.391, p < 0.01).
Conclusion: The mortality rates for the omicron variant are lower than for the preceding delta variant. mRNA vaccination affords secure and effective protection against severe disease and death from omicron.
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