优化种植体的骨结合、软组织反应和细菌抑制:对钛的紫外线光功能化多方面方法的全面综述。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-06-08 DOI:10.2186/jpr.JPR_D_24_00086
Gunwoo Park, Takanori Matsuura, Keiji Komatsu, Takahiro Ogawa
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引用次数: 0

摘要

钛种植体为修复和重建治疗带来了革命性的变化,但实现最佳骨结合和确保种植体长期成功仍是持续存在的挑战。在本综述中,我们将探讨一种增强种植体性能的前沿方法:紫外线(UV)光功能化。通过利用紫外线能量,光功能化使老化的种植体重新焕发青春,充分利用并经常超越钛材料的内在潜力。本综述的主要目的是对该领域取得的进展提供一个最新的视角,全面概述最新研究成果,并探讨紫外线诱导的物理化学改变与细胞反应之间的关系。现在有令人信服的证据表明,光功能化诱导钛表面化学发生了重大变化,从富含碳氢化合物的表面过渡到不含碳微粒的表面,产生了超亲水性表面,并调节了静电特性。这些变化与细胞附着、扩散、增殖、分化以及最终骨结合的改善密切相关。此外,我们还讨论了证明紫外线光功能化在加速和增强牙科植入物骨结合方面功效的临床研究。此外,我们还深入探讨了最近的进展,包括一分钟真空紫外线(VUV)光功能化的开发,它解决了传统紫外线方法的局限性,以及新发现的光功能化在调节软组织和细菌界面方面的功能。这项研究阐明了表面科学与生物学之间错综复杂的关系,为旨在提高钛种植体临床表现的创新策略奠定了基础,标志着种植学进入了一个新时代。
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Optimizing implant osseointegration, soft tissue responses, and bacterial inhibition: A comprehensive narrative review on the multifaceted approach of the UV photofunctionalization of titanium.

Titanium implants have revolutionized restorative and reconstructive therapy, yet achieving optimal osseointegration and ensuring long-term implant success remain persistent challenges. In this review, we explore a cutting-edge approach to enhancing implant properties: ultraviolet (UV) photofunctionalization. By harnessing UV energy, photofunctionalization rejuvenates aging implants, leveraging and often surpassing the intrinsic potential of titanium materials. The primary aim of this narrative review is to offer an updated perspective on the advancements made in the field, providing a comprehensive overview of recent findings and exploring the relationship between UV-induced physicochemical alterations and cellular responses. There is now compelling evidence of significant transformations in titanium surface chemistry induced by photofunctionalization, transitioning from hydrocarbon-rich to carbon pellicle-free surfaces, generating superhydrophilic surfaces, and modulating the electrostatic properties. These changes are closely associated with improved cellular attachment, spreading, proliferation, differentiation, and, ultimately, osseointegration. Additionally, we discuss clinical studies demonstrating the efficacy of UV photofunctionalization in accelerating and enhancing the osseointegration of dental implants. Furthermore, we delve into recent advancements, including the development of one-minute vacuum UV (VUV) photofunctionalization, which addresses the limitations of conventional UV methods as well as the newly discovered functions of photofunctionalization in modulating soft tissue and bacterial interfaces. By elucidating the intricate relationship between surface science and biology, this body of research lays the groundwork for innovative strategies aimed at enhancing the clinical performance of titanium implants, marking a new era in implantology.

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CiteScore
7.20
自引率
4.30%
发文量
567
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