Yao-Te Tsai MD, Liang-Tseng Kuo MD, Yun-Ting Wang MD, Andrea De Vito PhD, Sheng-Po Hao MD, Ku-Hao Fang MD, Yi-Chan Lee MD, Kuan-Yin Chen DDS, Chia-Hsuan Lai MD, Yuan-Hsiung Tsai PhD, Ethan I. Huang PhD, Ming-Shao Tsai MD, Cheng-Ming Hsu PhD, Geng-He Chang PhD, Chih-Wei Luan MD
{"title":"头颈癌老年营养风险指数的预后效用:系统回顾和荟萃分析。","authors":"Yao-Te Tsai MD, Liang-Tseng Kuo MD, Yun-Ting Wang MD, Andrea De Vito PhD, Sheng-Po Hao MD, Ku-Hao Fang MD, Yi-Chan Lee MD, Kuan-Yin Chen DDS, Chia-Hsuan Lai MD, Yuan-Hsiung Tsai PhD, Ethan I. Huang PhD, Ming-Shao Tsai MD, Cheng-Ming Hsu PhD, Geng-He Chang PhD, Chih-Wei Luan MD","doi":"10.1002/hed.27842","DOIUrl":null,"url":null,"abstract":"<p>We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random-effects meta-analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression-free survival (HR = 1.87, 95% CI = 1.32–2.65, <i>p</i> < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, <i>p</i> < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis\",\"authors\":\"Yao-Te Tsai MD, Liang-Tseng Kuo MD, Yun-Ting Wang MD, Andrea De Vito PhD, Sheng-Po Hao MD, Ku-Hao Fang MD, Yi-Chan Lee MD, Kuan-Yin Chen DDS, Chia-Hsuan Lai MD, Yuan-Hsiung Tsai PhD, Ethan I. Huang PhD, Ming-Shao Tsai MD, Cheng-Ming Hsu PhD, Geng-He Chang PhD, Chih-Wei Luan MD\",\"doi\":\"10.1002/hed.27842\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random-effects meta-analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression-free survival (HR = 1.87, 95% CI = 1.32–2.65, <i>p</i> < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, <i>p</i> < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.</p>\",\"PeriodicalId\":55072,\"journal\":{\"name\":\"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/hed.27842\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hed.27842","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis
We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random-effects meta-analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression-free survival (HR = 1.87, 95% CI = 1.32–2.65, p < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, p < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.
期刊介绍:
Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.