Jupen Liu, Bo Zhang, Zhe Lu, Ji-wei Shen, Ping Zhang and You Yu*,
{"title":"在体内进行具有正交近红外光化学作用的高性能上转换水凝胶界面工程设计,以实现无创生物膜消除和组织修复的协同作用","authors":"Jupen Liu, Bo Zhang, Zhe Lu, Ji-wei Shen, Ping Zhang and You Yu*, ","doi":"10.1021/acs.chemmater.4c01150","DOIUrl":null,"url":null,"abstract":"<p >NIR-mediated upconversion photochemistry stands as a powerful tool for noninvasive tissue engineering with excellent depth penetration. However, challenges such as low NIR upconversion and photochemical efficiencies, coupled with the moderate mechanical properties of upconversion hydrogels, hinder their advanced applications, particularly in oxygen- and water-rich physiological environments. This study addresses these limitations by strategically considering the interfacial effect and implementing a well-thought-out design for rapid NIR-mediated upconversion photochemistry, thereby developing high-performance upconversion hydrogels in vivo. Leveraging strong hydrophobic and electrostatic interactions at the interface of upconversion nanoparticles and hydrogel matrices enables us to achieve a remarkable 6-fold increase in fluorescent upconversion emission. This strategic enhancement in NIR photochemistry facilitates the rapid one-step formation of hierarchical upconversion hydrogels deep within tissues, significantly reducing fabrication time from approximately 6 min to 45 s. Meanwhile, these stretchable tough upconversion hydrogels experience impressive increases in mechanical properties by 3–10 times. Such rapid and controllable NIR photochemistry is compatible with standard printing techniques, allowing for the remote fabrication of complex structures beneath the skin. Moreover, as-prepared biocompatible upconversion hydrogels exhibit enhanced antimicrobial activity, surpassing typical bacteria, such as <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. With these notable advantages, the potential of this upconversion photochemistry extends beyond tissue engineering to include synergistic noninvasive biofilm elimination and tissue repair. Its promising applications span diverse fields, encompassing photochemistry, materials, engineering, and information sciences.</p>","PeriodicalId":33,"journal":{"name":"Chemistry of Materials","volume":null,"pages":null},"PeriodicalIF":7.2000,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Interfacial Engineering of High-Performance Upconversion Hydrogels with Orthogonal NIR Photochemistry in Vivo for Synergistic Noninvasive Biofilm Elimination and Tissue Repair\",\"authors\":\"Jupen Liu, Bo Zhang, Zhe Lu, Ji-wei Shen, Ping Zhang and You Yu*, \",\"doi\":\"10.1021/acs.chemmater.4c01150\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >NIR-mediated upconversion photochemistry stands as a powerful tool for noninvasive tissue engineering with excellent depth penetration. However, challenges such as low NIR upconversion and photochemical efficiencies, coupled with the moderate mechanical properties of upconversion hydrogels, hinder their advanced applications, particularly in oxygen- and water-rich physiological environments. This study addresses these limitations by strategically considering the interfacial effect and implementing a well-thought-out design for rapid NIR-mediated upconversion photochemistry, thereby developing high-performance upconversion hydrogels in vivo. Leveraging strong hydrophobic and electrostatic interactions at the interface of upconversion nanoparticles and hydrogel matrices enables us to achieve a remarkable 6-fold increase in fluorescent upconversion emission. This strategic enhancement in NIR photochemistry facilitates the rapid one-step formation of hierarchical upconversion hydrogels deep within tissues, significantly reducing fabrication time from approximately 6 min to 45 s. Meanwhile, these stretchable tough upconversion hydrogels experience impressive increases in mechanical properties by 3–10 times. Such rapid and controllable NIR photochemistry is compatible with standard printing techniques, allowing for the remote fabrication of complex structures beneath the skin. Moreover, as-prepared biocompatible upconversion hydrogels exhibit enhanced antimicrobial activity, surpassing typical bacteria, such as <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. With these notable advantages, the potential of this upconversion photochemistry extends beyond tissue engineering to include synergistic noninvasive biofilm elimination and tissue repair. 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Interfacial Engineering of High-Performance Upconversion Hydrogels with Orthogonal NIR Photochemistry in Vivo for Synergistic Noninvasive Biofilm Elimination and Tissue Repair
NIR-mediated upconversion photochemistry stands as a powerful tool for noninvasive tissue engineering with excellent depth penetration. However, challenges such as low NIR upconversion and photochemical efficiencies, coupled with the moderate mechanical properties of upconversion hydrogels, hinder their advanced applications, particularly in oxygen- and water-rich physiological environments. This study addresses these limitations by strategically considering the interfacial effect and implementing a well-thought-out design for rapid NIR-mediated upconversion photochemistry, thereby developing high-performance upconversion hydrogels in vivo. Leveraging strong hydrophobic and electrostatic interactions at the interface of upconversion nanoparticles and hydrogel matrices enables us to achieve a remarkable 6-fold increase in fluorescent upconversion emission. This strategic enhancement in NIR photochemistry facilitates the rapid one-step formation of hierarchical upconversion hydrogels deep within tissues, significantly reducing fabrication time from approximately 6 min to 45 s. Meanwhile, these stretchable tough upconversion hydrogels experience impressive increases in mechanical properties by 3–10 times. Such rapid and controllable NIR photochemistry is compatible with standard printing techniques, allowing for the remote fabrication of complex structures beneath the skin. Moreover, as-prepared biocompatible upconversion hydrogels exhibit enhanced antimicrobial activity, surpassing typical bacteria, such as Escherichia coli and Staphylococcus aureus. With these notable advantages, the potential of this upconversion photochemistry extends beyond tissue engineering to include synergistic noninvasive biofilm elimination and tissue repair. Its promising applications span diverse fields, encompassing photochemistry, materials, engineering, and information sciences.
期刊介绍:
The journal Chemistry of Materials focuses on publishing original research at the intersection of materials science and chemistry. The studies published in the journal involve chemistry as a prominent component and explore topics such as the design, synthesis, characterization, processing, understanding, and application of functional or potentially functional materials. The journal covers various areas of interest, including inorganic and organic solid-state chemistry, nanomaterials, biomaterials, thin films and polymers, and composite/hybrid materials. The journal particularly seeks papers that highlight the creation or development of innovative materials with novel optical, electrical, magnetic, catalytic, or mechanical properties. It is essential that manuscripts on these topics have a primary focus on the chemistry of materials and represent a significant advancement compared to prior research. Before external reviews are sought, submitted manuscripts undergo a review process by a minimum of two editors to ensure their appropriateness for the journal and the presence of sufficient evidence of a significant advance that will be of broad interest to the materials chemistry community.