铁状况、甲状腺功能障碍和缺铁性贫血:一项双样本孟德尔随机研究。

IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Annals of Nutrition and Metabolism Pub Date : 2024-06-10 DOI:10.1159/000539610
Xianjun Huang, Mingqiu Mao, Tianhong Guo, Yuqin Wu, Qi Xu, Junliang Dai, Yuanshuai Huang
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引用次数: 0

摘要

研究目的鉴于甲状腺功能障碍和缺铁性贫血(IDA)之间的临床关联,以及它们与铁状态之间的共同关联,本研究旨在探讨铁状态与甲状腺功能障碍之间的因果关系,同时还研究了与甲状腺功能障碍相关的IDA风险:方法:进行了一项双样本孟德尔随机化(MR)研究,以确定铁状态与甲状腺功能障碍的因果关系,以及甲状腺功能障碍与 IDA 的因果关系。研究利用了大型欧洲人群 GWAS 数据库(Genetics of Iron Status consortium、ThyroidOmics consortium、FinnGen consortium 和 UK biobank)。主要分析采用了逆方差加权(IVW)方法。此外,我们还使用了加权中位数和 MR-Egger 来增强稳健性。我们还进行了敏感性分析,以评估 MR 结果的稳健性:结果:IVW估计值并未显示血清铁状态标记物与甲状腺功能障碍之间存在任何显著的因果关系。然而,甲状腺功能减退症与 IDA 之间存在明显的因果关系(OR = 1.101,95% CI = 1.048-1.157,p <0.001)。重复分析也显示出类似的趋势(OR = 1.023,95% CI = 1.011-1.035,p <0.001)。敏感性分析表明,MR 估计值是稳健的:在我们的MR研究中,发现甲状腺功能减退症相关基因的上调与欧洲人群罹患IDA的风险升高显著相关。这些发现可能会为临床医生管理甲状腺功能减退症、IDA 或其合并症患者提供新的治疗思路。
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Iron Status, Thyroid Dysfunction, and Iron Deficiency Anemia: A Two-Sample Mendelian Randomization Study.

Introduction: Given the clinical association between thyroid dysfunction and iron deficiency anemia (IDA), as well as their shared association with iron status, this study aimed to investigate the causal relationship between iron status and thyroid dysfunction, while also examining the risk of IDA in relation to thyroid dysfunction.

Methods: A two-sample mendelian randomization (MR) study was conducted to identify the causal relationship of iron status on thyroid dysfunction, as well as thyroid dysfunction on IDA. Large-scale European population-based genome-wide association study databases were utilized (Genetics of Iron Status consortium, ThyroidOmics consortium, FinnGen consortium, and UK Biobank). Inverse variance-weighted (IVW) was used as the main analysis. In addition, we used weighted median and MR-Egger to enhance the robustness. Sensitivity analysis was conducted to evaluate the robustness of MR results.

Results: The IVW estimates did not reveal any significant causal relationship between serum iron status markers and thyroid dysfunction. However, a significant causal relationship was observed between hypothyroidism and IDA (odds ratio [OR] = 1.101, 95% confidence interval [CI] = 1.048-1.157, p < 0.001). Repeated analyses also demonstrated a similar trend (OR = 1.023, 95% CI = 1.011-1.035, p < 0.001). Sensitivity analysis supported that the MR estimates were robust.

Conclusion: In our MR study, an upregulation of the hypothyroidism-associated gene was found to be significantly associated with an elevated risk of IDA in the European population. These findings may offer novel therapeutic insights for clinicians managing patients with hypothyroidism, IDA, or their comorbidities.

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来源期刊
Annals of Nutrition and Metabolism
Annals of Nutrition and Metabolism 医学-内分泌学与代谢
CiteScore
6.50
自引率
0.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.
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