一项纵向研究:青壮年补充降钙素后体重指数对血清 25- 羟维生素 D 和 1,25- 二羟维生素 D 的影响。

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine Pub Date : 2024-10-01 Epub Date: 2024-06-11 DOI:10.1007/s12020-024-03895-0
Liza Das, Naresh Sachdeva, Michael F Holick, Mahesh Devnani, Pinaki Dutta, Raman Kumar Marwaha
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引用次数: 0

摘要

背景:高体重指数(BMI)是维生素 D 缺乏的一个风险因素。补充胆钙化醇后,血清中 25- 羟维生素 D [25(OH)D] 浓度的升高并不理想,原因是脂肪组织螯合和/或体积稀释。骨化二醇已被证明是一种有效的口服维生素 D 补充剂,但体重指数是否会对其提高 25(OH)D 浓度的效果产生不利影响,目前尚不清楚:根据体重指数分类,对血清中 25(OH)D 浓度为 2D 的成人进行研究(n = 883)。对一部分参与者补充 50 µg 降钙二醇(n = 193),并在补充 3 个月和 6 个月后评估血清中 25(OH)D 浓度的上升情况:参与者被分为肥胖(11.2%)、超重(32.1%)或正常体重(56.7%)。各组血清中 25(OH)D 浓度的基线差异不大(13.1 ± 6.4 vs 12.8 ± 6.8 vs 11.6 ± 6.6 ng/mL,p = 0.62)。同样,各组间的 PTH 或 1,25(OH)2D 浓度也没有差异。在随访中,所有三组的 25(OH)D 浓度在 3 个月和 6 个月时都比基线时有所增加。肥胖组的 25(OH)D 浓度在 3 个月时增加了 74.4 纳克/毫升(IQR 35.3-115.3),其次是超重组 62.2 纳克/毫升(18.1-98.7)和正常体重组 47.1 纳克/毫升(17.5-89.7)。1,25(OH)2D 也在所有组别中增加,但组间差异不明显(P > 0.05):结论:维生素 D 缺乏的年轻人在补充降钙素后,体重指数不会阻碍 25(OH)D 浓度的上升。
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Impact of BMI on serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with calcifediol supplementation in young adults: a longitudinal study.

Background: High body mass index (BMI) is a risk factor for vitamin D deficiency. The rise in serum 25-hydroxyvitamin D [25(OH)D] concentrations following cholecalciferol supplementation is suboptimal, owing to adipose tissue sequestration and/or volumetric dilution. Calcifediol is a proven potent oral alternative for vitamin D supplementation, but whether BMI adversely affects its efficacy in raising 25(OH)D concentrations, is not well known.

Material and methods: Adults with serum concentrations of 25(OH)D < 30 ng/mL were recruited and stratified as normal, overweight, or obese using WHO criteria. Baseline evaluation included 25(OH)D, parathyroid hormone (PTH), and total 1,25-dihydroxyvitamin D [1,25(OH)2D] based on BMI category (n = 883). A subset of participants was supplemented with 50 µg calcifediol (n = 193) and assessed for the rise in serum concentrations of 25(OH)D at 3- and 6-months following supplementation.

Results: Participants were stratified as obese (11.2%), overweight (32.1%), or normal weight (56.7%). There were no significant baseline differences in serum concentrations of 25(OH)D among the groups (13.1 ± 6.4 vs 12.8 ± 6.8 vs 11.6 ± 6.6 ng/mL, p = 0.62). Similarly, PTH or 1,25(OH)2D concentrations were not different among the groups. On follow-up, 25(OH)D concentrations increased in all three groups at 3 and 6 months from baseline. The increase in 25(OH)D was 74.4 ng/mL (IQR 35.3-115.3) in obese, followed by overweight 62.2 ng/mL (18.1-98.7) and normal weight groups 47.1 ng/mL (17.5-89.7) at 3 months. 1,25(OH)2D also increased in all groups, without any significant intergroup differences (p > 0.05).

Conclusion: BMI does not impede the rise in 25(OH)D concentrations following supplementation with calcifediol in young adults with vitamin D deficiency.

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来源期刊
Endocrine
Endocrine ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
5.40%
发文量
295
审稿时长
1.5 months
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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