Matheus Braga, Mariana Akemi Sonoda Shiga, Pedro Emanuel Santiago Silva, Aléia Harumi Uchibaba Yamanaka, Victor Hugo Souza, Sergio Grava, Andréa Name Colado Simão, Janisleya Silva Ferreira Neves, Quirino Alves de Lima Neto, Joana Maira Valentini Zacarias, Jeane Eliete Laguila Visentainer
{"title":"巴西南部 TLR3、TICAM1 和 IFNA1 基因的多态性与 covid-19 严重程度之间的关系。","authors":"Matheus Braga, Mariana Akemi Sonoda Shiga, Pedro Emanuel Santiago Silva, Aléia Harumi Uchibaba Yamanaka, Victor Hugo Souza, Sergio Grava, Andréa Name Colado Simão, Janisleya Silva Ferreira Neves, Quirino Alves de Lima Neto, Joana Maira Valentini Zacarias, Jeane Eliete Laguila Visentainer","doi":"10.1080/14737159.2024.2367466","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>A distinct phenotype in Coronavirus disease 2019 (Covid-19) was observed in severe patients, consisting of a highly impaired interferon (IFN) type I response, an exacerbated inflammatory response.</p><p><strong>Objective: </strong>The aim of the present study was to investigate a possible association of single nucleotide polymorphisms (SNPs), in five genes related to the immune response, rs3775291 in <i>TLR3</i>; rs2292151 in <i>TICAM1</i>; rs1758566 in <i>IFNA1</i>; rs1800629 in <i>TNF</i>, and rs1800795 in <i>IL6</i> with the severity of Covid-19.</p><p><strong>Methods: </strong>A cross-sectional study was performed, with non-severe and severe/critical patients diagnosed with Covid-19, by two public hospitals in Brazil. In total, 300 patients were genotyped for the SNPs, 150 with the non-severe form of the disease and 150 with severe/critical form.</p><p><strong>Results: </strong>The T/T genotype of <i>TLR3</i> in recessive model shows 58% of protection against severe/critical Covid-19; as well as the genotypes G/A+A/A of <i>TICAM1</i> in dominant model with 60% of protection, and in a codominant model G/A with 57% and A/A with 71% of protection against severe/critical Covid-19. Comparing severe and critical cases, the T/C genotype of <i>IFNA1</i> in the codominant model and TC+C/C in the dominant model showed twice the risk of critical Covid-19.</p><p><strong>Conclusion: </strong>We can conclude that rs3775291, rs2292151 and rs1758566 can influence the COVID-19 severity.</p>","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"525-531"},"PeriodicalIF":3.9000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between polymorphisms in <i>TLR3</i>, <i>TICAM1</i> and <i>IFNA1</i> genes and covid-19 severity in Southern Brazil.\",\"authors\":\"Matheus Braga, Mariana Akemi Sonoda Shiga, Pedro Emanuel Santiago Silva, Aléia Harumi Uchibaba Yamanaka, Victor Hugo Souza, Sergio Grava, Andréa Name Colado Simão, Janisleya Silva Ferreira Neves, Quirino Alves de Lima Neto, Joana Maira Valentini Zacarias, Jeane Eliete Laguila Visentainer\",\"doi\":\"10.1080/14737159.2024.2367466\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>A distinct phenotype in Coronavirus disease 2019 (Covid-19) was observed in severe patients, consisting of a highly impaired interferon (IFN) type I response, an exacerbated inflammatory response.</p><p><strong>Objective: </strong>The aim of the present study was to investigate a possible association of single nucleotide polymorphisms (SNPs), in five genes related to the immune response, rs3775291 in <i>TLR3</i>; rs2292151 in <i>TICAM1</i>; rs1758566 in <i>IFNA1</i>; rs1800629 in <i>TNF</i>, and rs1800795 in <i>IL6</i> with the severity of Covid-19.</p><p><strong>Methods: </strong>A cross-sectional study was performed, with non-severe and severe/critical patients diagnosed with Covid-19, by two public hospitals in Brazil. In total, 300 patients were genotyped for the SNPs, 150 with the non-severe form of the disease and 150 with severe/critical form.</p><p><strong>Results: </strong>The T/T genotype of <i>TLR3</i> in recessive model shows 58% of protection against severe/critical Covid-19; as well as the genotypes G/A+A/A of <i>TICAM1</i> in dominant model with 60% of protection, and in a codominant model G/A with 57% and A/A with 71% of protection against severe/critical Covid-19. Comparing severe and critical cases, the T/C genotype of <i>IFNA1</i> in the codominant model and TC+C/C in the dominant model showed twice the risk of critical Covid-19.</p><p><strong>Conclusion: </strong>We can conclude that rs3775291, rs2292151 and rs1758566 can influence the COVID-19 severity.</p>\",\"PeriodicalId\":12113,\"journal\":{\"name\":\"Expert Review of Molecular Diagnostics\",\"volume\":\" \",\"pages\":\"525-531\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Expert Review of Molecular Diagnostics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/14737159.2024.2367466\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Molecular Diagnostics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14737159.2024.2367466","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/17 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil.
Background: A distinct phenotype in Coronavirus disease 2019 (Covid-19) was observed in severe patients, consisting of a highly impaired interferon (IFN) type I response, an exacerbated inflammatory response.
Objective: The aim of the present study was to investigate a possible association of single nucleotide polymorphisms (SNPs), in five genes related to the immune response, rs3775291 in TLR3; rs2292151 in TICAM1; rs1758566 in IFNA1; rs1800629 in TNF, and rs1800795 in IL6 with the severity of Covid-19.
Methods: A cross-sectional study was performed, with non-severe and severe/critical patients diagnosed with Covid-19, by two public hospitals in Brazil. In total, 300 patients were genotyped for the SNPs, 150 with the non-severe form of the disease and 150 with severe/critical form.
Results: The T/T genotype of TLR3 in recessive model shows 58% of protection against severe/critical Covid-19; as well as the genotypes G/A+A/A of TICAM1 in dominant model with 60% of protection, and in a codominant model G/A with 57% and A/A with 71% of protection against severe/critical Covid-19. Comparing severe and critical cases, the T/C genotype of IFNA1 in the codominant model and TC+C/C in the dominant model showed twice the risk of critical Covid-19.
Conclusion: We can conclude that rs3775291, rs2292151 and rs1758566 can influence the COVID-19 severity.
期刊介绍：
Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting.
Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy.
Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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