血清磷脂酶 A2 受体抗体与特发性膜性肾病患者的血栓形成有关。

IF 2.3 4区医学 Q2 PERIPHERAL VASCULAR DISEASE Kidney & blood pressure research Pub Date : 2024-01-01 Epub Date: 2024-06-12 DOI:10.1159/000539437

Qinling Zhang, Guiling Liu

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引用次数: 0

摘要

导言：特发性膜性肾病（IMN）患者特别容易发生血栓栓塞（TE）。磷脂酶 A2 受体（PLA2R）抗体（Ab）被认为是特发性膜性肾病静脉血栓栓塞症的独立风险预测因子。本研究旨在进一步探讨 PLA2R 抗体对 IMN 患者静脉和动脉 TE 的预测价值：方法：回顾性筛选出 91 例 IMN 患者，根据抗 PLA2R Ab 滴度（临界值：20 RU/mL）将其分为抗 PLA2R 阳性组和抗 PLA2R 阴性组。血清 PLA2R 抗体用酶联免疫吸附法估算。根据是否存在 TE，抗-PLA2R 阳性的 IMN 患者被进一步分为两组：12例（18.18%）抗PLA2R阳性的IMN患者出现TE，包括静脉和动脉TE。抗-PLA2R阴性组未出现TE。抗-PLA2R 阳性组 IMN 患者的总胆固醇和低密度脂蛋白水平明显高于抗-PLA2R 阴性组。抗PLA2R抗体滴度在有TE和无TE的患者之间未观察到明显差异。有TE的患者年龄明显大于无TE的患者：本研究表明，抗PLA2R抗体阳性是IMN血栓形成的原因之一。

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Serum Phospholipase A2 Receptor Antibody Is Associated with Thrombogenesis in Patients with Idiopathic Membranous Nephropathy.

Introduction: Patients with idiopathic membranous nephropathy (IMN) are particularly susceptible to thromboembolism (TE). The phospholipase A2 receptor (PLA2R) antibody (Ab) has been indicated to work as an independent risk predictor for venous TE in IMN. This study aimed to further explore the predictive value of PLA2R Ab for both venous and arterial TE in IMN patients.

Methods: A total of 91 IMN patients were retrospectively selected and divided into anti-PLA2R-positive or anti-PLA2R-negative groups according to the anti-PLA2R Ab titer (cutoff: 20 RU/mL). Serum PLA2R Abs were estimated using ELISA. Anti-PLA2R-positive IMN patients were further assigned into two groups based on the presence or absence of TE.

Results: Twelve (18.18%) IMN patients with anti-PLA2R positivity had TE, including both venous and arterial TE. No TE occurred in the anti-PLA2R-negative group. IMN patients in the anti-PLA2R-positive group had significantly higher levels of total cholesterol and low-density lipoprotein than those in the anti-PLA2R-negative group. No significant difference was observed in the anti-PLA2R Ab titer between patients with and without TE. Patients with TE were significantly older than those without TE.

Conclusion: This study demonstrates that the positive status of anti-PLA2R Abs contributes to thrombosis formation in IMN.

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来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.