骨-器官轴:双向串扰。

IF 16.7 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Military Medical Research Pub Date : 2024-06-12 DOI:10.1186/s40779-024-00540-9
An-Fu Deng, Fu-Xiao Wang, Si-Cheng Wang, Ying-Ze Zhang, Long Bai, Jia-Can Su
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引用次数: 0

摘要

除了在提供结构支撑方面的公认作用外,骨骼还通过分泌特定的细胞因子(也称为骨激酶),在维持各种器官的功能和平衡方面发挥着至关重要的作用。这种相互影响延伸到这些调节骨平衡和发育的器官,但这方面的研究还没有系统的综述。本综述旨在阐明这种双向的相互影响,尤其关注骨生成素的作用。此外,这篇综述还提供了一份独特的证据汇编,首次强调了细胞外小泡(EVs)在骨-器官轴中的关键功能。此外,它还探讨了这种串扰对设计和实施片上骨和装配体的影响,强调了理解这些相互作用对推进生理相关体外模型的重要性。因此,这篇综述从细胞因子、EVs、激素和代谢物的角度为预防、诊断和治疗与骨-器官轴相关的疾病奠定了坚实的理论基础。
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Bone-organ axes: bidirectional crosstalk.

In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteokines). This reciprocal influence extends to these organs modulating bone homeostasis and development, although this aspect has yet to be systematically reviewed. This review aims to elucidate this bidirectional crosstalk, with a particular focus on the role of osteokines. Additionally, it presents a unique compilation of evidence highlighting the critical function of extracellular vesicles (EVs) within bone-organ axes for the first time. Moreover, it explores the implications of this crosstalk for designing and implementing bone-on-chips and assembloids, underscoring the importance of comprehending these interactions for advancing physiologically relevant in vitro models. Consequently, this review establishes a robust theoretical foundation for preventing, diagnosing, and treating diseases related to the bone-organ axis from the perspective of cytokines, EVs, hormones, and metabolites.

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来源期刊
Military Medical Research
Military Medical Research Medicine-General Medicine
CiteScore
38.40
自引率
2.80%
发文量
485
审稿时长
8 weeks
期刊介绍: Military Medical Research is an open-access, peer-reviewed journal that aims to share the most up-to-date evidence and innovative discoveries in a wide range of fields, including basic and clinical sciences, translational research, precision medicine, emerging interdisciplinary subjects, and advanced technologies. Our primary focus is on modern military medicine; however, we also encourage submissions from other related areas. This includes, but is not limited to, basic medical research with the potential for translation into practice, as well as clinical research that could impact medical care both in times of warfare and during peacetime military operations.
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