Joshua G. Kovoor , Christopher K. Rayner , Tongzhi Wu , Ryan J. Jalleh , Guy J. Maddern , Michael Horowitz , Karen L. Jones
{"title":"利昔那肽对2型糖尿病患者液态胃排空的影响--对手术前使用GLP-1受体激动剂的启示","authors":"Joshua G. Kovoor , Christopher K. Rayner , Tongzhi Wu , Ryan J. Jalleh , Guy J. Maddern , Michael Horowitz , Karen L. Jones","doi":"10.1016/j.jdiacomp.2024.108793","DOIUrl":null,"url":null,"abstract":"<div><p>Gastric emptying of a glucose drink was measured in people with type 2 diabetes given lixisenatide (20 μg/day or placebo) for 8 weeks. Intragastric retention at 240 min (2 (0−11)% vs 48 (3–97)%; <em>P</em> < 0.0001) was much greater with lixisenatide than placebo. Accordingly, lixisenatide may delay liquid gastric emptying markedly.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108793"},"PeriodicalIF":2.9000,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001193/pdfft?md5=59e914b64633c07c93d231e8dba7b5e2&pid=1-s2.0-S1056872724001193-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Effect of lixisenatide on liquid gastric emptying in type 2 diabetes – Implications for the use of GLP-1 receptor agonists before procedures\",\"authors\":\"Joshua G. Kovoor , Christopher K. Rayner , Tongzhi Wu , Ryan J. Jalleh , Guy J. Maddern , Michael Horowitz , Karen L. Jones\",\"doi\":\"10.1016/j.jdiacomp.2024.108793\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Gastric emptying of a glucose drink was measured in people with type 2 diabetes given lixisenatide (20 μg/day or placebo) for 8 weeks. Intragastric retention at 240 min (2 (0−11)% vs 48 (3–97)%; <em>P</em> < 0.0001) was much greater with lixisenatide than placebo. Accordingly, lixisenatide may delay liquid gastric emptying markedly.</p></div>\",\"PeriodicalId\":15659,\"journal\":{\"name\":\"Journal of diabetes and its complications\",\"volume\":\"38 8\",\"pages\":\"Article 108793\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-06-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1056872724001193/pdfft?md5=59e914b64633c07c93d231e8dba7b5e2&pid=1-s2.0-S1056872724001193-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of diabetes and its complications\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1056872724001193\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of diabetes and its complications","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1056872724001193","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
对服用利西那肽（20 微克/天或安慰剂）8 周的 2 型糖尿病患者进行了葡萄糖饮料胃排空测定。240分钟时的胃内滞留率（2 (0-11)% vs 48 (3-97)%; P < 0.0001）利西那肽远高于安慰剂。因此，利血那肽可明显延迟液态胃排空。
Effect of lixisenatide on liquid gastric emptying in type 2 diabetes – Implications for the use of GLP-1 receptor agonists before procedures
Gastric emptying of a glucose drink was measured in people with type 2 diabetes given lixisenatide (20 μg/day or placebo) for 8 weeks. Intragastric retention at 240 min (2 (0−11)% vs 48 (3–97)%; P < 0.0001) was much greater with lixisenatide than placebo. Accordingly, lixisenatide may delay liquid gastric emptying markedly.
期刊介绍：
Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis.
The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications.
Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
