狼疮中微生物组与免疫代谢的交叉。

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2024-06-14 DOI:10.1111/imr.13360
Abigail Castellanos Garcia, Natalie Six, Longhuan Ma, Laurence Morel
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引用次数: 0

摘要

系统性红斑狼疮是一种复杂的自身免疫性疾病,由免疫系统失调引起,涉及肠道菌群失调和宿主细胞代谢改变。这篇综述重点介绍了新的见解,并阐述了狼疮中肠道微生物组和宿主免疫代谢之间的相互作用。病原菌、入侵性病原体甚至共生微生物在菌群失调时,都能通过代谢重编程触发和调节免疫反应。微生物群整体组成或单个类群的变化可能会引发免疫细胞的一连串代谢变化,进而对其功能进行重编程。导致菌群失调的因素包括肠道缺氧的变化、对葡萄糖的竞争以及色氨酸和金属离子等必需营养物质的有限供应,所有这些因素都可能受到宿主代谢变化的驱动。相反,一些宿主代谢物(如伊他康酸、琥珀酸和游离脂肪酸)的积累也会进一步影响微生物的组成和免疫反应。总之,越来越多的证据支持狼疮发病机制中宿主免疫代谢与微生物群之间存在双向关系。
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Intersection of the microbiome and immune metabolism in lupus

Systemic lupus erythematosus is a complex autoimmune disease resulting from a dysregulation of the immune system that involves gut dysbiosis and an altered host cellular metabolism. This review highlights novel insights and expands on the interactions between the gut microbiome and the host immune metabolism in lupus. Pathobionts, invasive pathogens, and even commensal microbes, when in dysbiosis, can all trigger and modulate immune responses through metabolic reprogramming. Changes in the microbiota's global composition or individual taxa may trigger a cascade of metabolic changes in immune cells that may, in turn, reprogram their functions. Factors contributing to dysbiosis include changes in intestinal hypoxia, competition for glucose, and limited availability of essential nutrients, such as tryptophan and metal ions, all of which can be driven by host metabolism changes. Conversely, the accumulation of some host metabolites, such as itaconate, succinate, and free fatty acids, could further influence the microbial composition and immune responses. Overall, mounting evidence supports a bidirectional relationship between host immunometabolism and the microbiota in lupus pathogenesis.

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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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