肠内分泌轴及其对胃肠功能、营养和炎症的影响。

IF 3.5 3区 医学 Q1 CRITICAL CARE MEDICINE Current Opinion in Critical Care Pub Date : 2024-08-01 Epub Date: 2024-06-13 DOI:10.1097/MCC.0000000000001175
Jordan D Philpott, K Marco Rodriguez Hovnanian, Margaret Stefater-Richards, Nilesh M Mehta, Enid E Martinez
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引用次数: 0

摘要

综述目的:危重症患者的胃肠道(GI)功能障碍会限制肠内营养(EN)的输送,并导致全身性炎症。肠道内分泌(EE)轴在危重症患者的营养、炎症和胃肠道功能之间起着不可或缺的作用。在这篇综述中,我们概述了肠内分泌系统,重点介绍了它在消化道炎症和功能中的作用:最近的研究结果:肠内分泌细胞主要在宏量营养素消化和吸收方面发挥作用。最近的研究扩展了肠内分泌细胞的多种功能,包括感知微生物肽和代谢物以及调节免疫功能和炎症的能力。因此,EE 细胞既可能受到许多病理生理状态和危重病干预措施(如菌群失调、炎症和替代 EN 策略)的影响,也可能对其做出贡献。在这篇综述中,我们概述了 EE 细胞,包括它们在非营养功能中日益增长的作用,并将这一认识融入危重病的相关方面,重点关注 EN。摘要:EE 系统是危重病中维持消化道平衡的关键,在危重病中,它如何受到菌群失调、炎症和不同喂养策略的影响并对结果做出贡献,应加以考虑。
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The enteroendocrine axis and its effect on gastrointestinal function, nutrition, and inflammation.

Purpose of review: Gastrointestinal (GI) dysfunction limits enteral nutrition (EN) delivery in critical illness and contributes to systemic inflammation. The enteroendocrine (EE) axis plays an integral role in this interface between nutrition, inflammation, and GI function in critical illness. In this review, we present an overview of the EE system with a focus on its role in GI inflammation and function.

Recent findings: Enteroendocrine cells have been primarily described in their role in macronutrient digestion and absorption. Recent research has expanded on the diverse functions of EE cells including their ability to sense microbial peptides and metabolites and regulate immune function and inflammation. Therefore, EE cells may be both affected by and contribute to many pathophysiologic states and interventions of critical illness such as dysbiosis , inflammation, and alternative EN strategies. In this review, we present an overview of EE cells including their growing role in nonnutrient functions and integrate this understanding into relevant aspects of critical illness with a focus on EN.

Summary: The EE system is key in maintaining GI homeostasis in critical illness, and how it is impacted and contributes to outcomes in the setting of dysbiosis , inflammation and different feeding strategies in critical illness should be considered.

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来源期刊
Current Opinion in Critical Care
Current Opinion in Critical Care 医学-危重病医学
CiteScore
5.90
自引率
3.00%
发文量
172
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​​​Current Opinion in Critical Care delivers a broad-based perspective on the most recent and most exciting developments in critical care from across the world. Published bimonthly and featuring thirteen key topics – including the respiratory system, neuroscience, trauma and infectious diseases – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.
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