单克隆抗体病相关周围神经病:发现珍珠与挑战。

IF 3.9 3区 医学 Q1 CLINICAL NEUROLOGY Journal of the Peripheral Nervous System Pub Date : 2024-06-14 DOI:10.1111/jns.12638
Trajano Aguiar Pires Gonçalves, Camila Derminio Donadel, Rodrigo Siqueira Soares Frezatti, Pedro Manoel Marques Garibaldi, Rodrigo T. Calado, Wilson Marques Junior, Pedro José Tomaselli
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引用次数: 0

摘要

单克隆丙种球蛋白病相关周围神经病包括一系列临床表现,其中单克隆蛋白直接损害组织,包括周围神经系统。鉴于周围神经病变和单克隆抗体病在普通人群中的发病率较高,这些病症在临床实践中可能会出现重叠,给临床医生确定因果关系带来了挑战。因此,全面了解原发性临床综合征及其神经生理学模式对于准确鉴别诊断和有效治疗策略至关重要。在本文中,我们将探讨影响周围神经的单克隆丙种球蛋白病的主要形式。我们探讨了临床和电生理学方面的问题,以及它们与每种综合征的相应单克隆蛋白类型之间的相关性。这些知识对于医护人员更好地诊断和管理单克隆丙种球蛋白病相关周围神经系统受累的患者至关重要。
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Monoclonal gammopathy-associated peripheral neuropathies: Uncovering pearls and challenges

Monoclonal gammopathy-related peripheral neuropathies encompass a spectrum of clinical presentations in which the monoclonal protein directly damages the tissues, including the peripheral nervous system. Given the prevalence of both peripheral neuropathy and monoclonal gammopathy in the general population, these conditions may overlap in clinical practice, posing a challenge for clinicians in determining causality. Therefore, a comprehensive understanding of primary clinical syndromes and their neurophysiological patterns is of great importance for accurate differential diagnoses and effective treatment strategies. In this article, we examine the main forms of monoclonal gammopathies that affect the peripheral nerve. We explore the clinical and electrophysiological aspects and their correlation with each syndrome's corresponding monoclonal protein type. This knowledge is essential for healthcare professionals to diagnose better and manage patients presenting with monoclonal gammopathy-related peripheral nervous system involvement.

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来源期刊
CiteScore
6.10
自引率
7.90%
发文量
45
审稿时长
>12 weeks
期刊介绍: The Journal of the Peripheral Nervous System is the official journal of the Peripheral Nerve Society. Founded in 1996, it is the scientific journal of choice for clinicians, clinical scientists and basic neuroscientists interested in all aspects of biology and clinical research of peripheral nervous system disorders. The Journal of the Peripheral Nervous System is a peer-reviewed journal that publishes high quality articles on cell and molecular biology, genomics, neuropathic pain, clinical research, trials, and unique case reports on inherited and acquired peripheral neuropathies. Original articles are organized according to the topic in one of four specific areas: Mechanisms of Disease, Genetics, Clinical Research, and Clinical Trials. The journal also publishes regular review papers on hot topics and Special Issues on basic, clinical, or assembled research in the field of peripheral nervous system disorders. Authors interested in contributing a review-type article or a Special Issue should contact the Editorial Office to discuss the scope of the proposed article with the Editor-in-Chief.
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