评估超声散射模型的散射参数,考虑细胞颗粒生物体和体内肿瘤的细胞核和细胞的散射。

IF 2.5 4区 医学 Q1 ACOUSTICS Ultrasonic Imaging Pub Date : 2024-09-01 Epub Date: 2024-06-14 DOI:10.1177/01617346241256120
Pauline Muleki-Seya, William D O'Brien
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引用次数: 0

摘要

定量超声后向散射系数可评估组织微观结构参数。基于组织的散射体参数是利用超声散射模型提取的。从光学测量的组织学中关联组织结构的超声散射体参数具有挑战性,这可能是因为散射模型不合适或存在多个散射体。本研究的目的是利用考虑到细胞核和细胞的超声散射的散射模型来量化相关的散射体参数。同心球体模型(CSM)和针对两种类型散射体的结构因子模型(SFM2)针对细胞颗粒生物体和四种细胞系的体外肿瘤进行了评估:4T1、JC、LMTK 和 MAT。结构因子模型(SFM)用于比较。与 SFM 相比,CSM 和 SFM2 提供的细胞核和细胞半径及体积分数的散射体参数更接近组织学(相对误差更小),但散射体分布的离散性并不总是更低(变异系数更小)。与 SFM 相比,CSM 和 SFM2 量化细胞和细胞核半径及体积分数参数的相对误差更小。在肿瘤方面,CSM 的结果优于 SFM2。
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Evaluation of Scatterer Parameters From Ultrasound Scattering Models Taking Into Account Scattering From Nuclei and Cells of Cell-Pellet Biophantoms and Ex Vivo Tumors.

The Quantitative Ultrasound backscatter coefficient provides the capability to evaluate tissue microstructure parameters. Tissue-based scatterer parameters are extracted using ultrasound scattering models. It is challenging to correlate ultrasound scatterer parameters of tissue structures from optical-measured histology, possibly because of inappropriate scattering models or the presence of multiple scatterers. The objective of this study is to pursue the quantification of pertinent scatterer parameters with scattering models that consider ultrasound scattering from nuclei and cells. The concentric sphere model (CSM) and the structure factor model adapted for two types of scatterers (SFM2) are evaluated for cell-pellet biophantoms and ex vivo tumors of four cell lines: 4T1, JC, LMTK, and MAT. The structure factor model (SFM) was used for comparison. CSM and SFM2 provided scatterer parameters closer to histology (lower relative errors) for nucleus and cell radii and volume fractions than SFM but were not always accompanied by lower dispersion of the scatterer distribution (lower coefficient of variation). CSM and SFM2 quantified cell and nucleus radius and volume fraction parameters with lower relative error compared to SFM. For tumors, CSM provided better results than SFM2.

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来源期刊
Ultrasonic Imaging
Ultrasonic Imaging 医学-工程:生物医学
CiteScore
5.10
自引率
8.70%
发文量
15
审稿时长
>12 weeks
期刊介绍: Ultrasonic Imaging provides rapid publication for original and exceptional papers concerned with the development and application of ultrasonic-imaging technology. Ultrasonic Imaging publishes articles in the following areas: theoretical and experimental aspects of advanced methods and instrumentation for imaging
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