{"title":"评估近红外触发 PEG 涂层 NaGdF4:Tm3+/Yb3+ 生物兼容上转换纳米粒子在 OCT 成像和光学测温中的对比度增强作用。","authors":"Kumar Shwetabh, Abhishek Banerjee, Raju Poddar, Kaushal Kumar","doi":"10.1088/1748-605X/ad580b","DOIUrl":null,"url":null,"abstract":"<p><p>In this investigation, we embarked on the synthesis of polyethylene glycol coated NaGdF<sub>4</sub>:Tm<sup>3+</sup>/Yb<sup>3+</sup>upconversion nanoparticles (UCNPs), aiming to assess their utility in enhancing image contrast within the context of swept source optical coherence tomography (OCT) and photo-thermal OCT imaging. Our research unveiled the remarkable UC emissions stemming from the transitions of Tm<sup>3+</sup>ions, specifically the<sup>1</sup>G<sub>4</sub>→<sup>3</sup>H<sub>6</sub>transitions, yielding vibrant blue emissions at 472 nm. We delved further into the UC mechanism, meticulously scrutinizing decay times and the nanoparticles' capacity to convert radiation into heat. Notably, these nanoparticles exhibited an impressive photo-thermal conversion efficiency of 37.5%. Furthermore, our investigations into their bio-compatibility revealed a promising outcome, with more than 90% cell survival after 24 h of incubation with HeLa cells treated with UCNPs. The nanoparticles demonstrated a notable thermal sensitivity of 4.7 × 10<sup>-3</sup>K<sup>-1</sup>at 300 K, signifying their potential for precise temperature monitoring at the cellular level.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessment of NIR-triggered PEG-coated NaGdF<sub>4</sub>:Tm<sup>3+</sup>/Yb<sup>3+</sup>bio-compatible upconversion nanoparticles for contrast enhancement in OCT imaging and optical thermometry.\",\"authors\":\"Kumar Shwetabh, Abhishek Banerjee, Raju Poddar, Kaushal Kumar\",\"doi\":\"10.1088/1748-605X/ad580b\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this investigation, we embarked on the synthesis of polyethylene glycol coated NaGdF<sub>4</sub>:Tm<sup>3+</sup>/Yb<sup>3+</sup>upconversion nanoparticles (UCNPs), aiming to assess their utility in enhancing image contrast within the context of swept source optical coherence tomography (OCT) and photo-thermal OCT imaging. Our research unveiled the remarkable UC emissions stemming from the transitions of Tm<sup>3+</sup>ions, specifically the<sup>1</sup>G<sub>4</sub>→<sup>3</sup>H<sub>6</sub>transitions, yielding vibrant blue emissions at 472 nm. We delved further into the UC mechanism, meticulously scrutinizing decay times and the nanoparticles' capacity to convert radiation into heat. Notably, these nanoparticles exhibited an impressive photo-thermal conversion efficiency of 37.5%. Furthermore, our investigations into their bio-compatibility revealed a promising outcome, with more than 90% cell survival after 24 h of incubation with HeLa cells treated with UCNPs. The nanoparticles demonstrated a notable thermal sensitivity of 4.7 × 10<sup>-3</sup>K<sup>-1</sup>at 300 K, signifying their potential for precise temperature monitoring at the cellular level.</p>\",\"PeriodicalId\":72389,\"journal\":{\"name\":\"Biomedical materials (Bristol, England)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical materials (Bristol, England)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1088/1748-605X/ad580b\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical materials (Bristol, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1088/1748-605X/ad580b","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Assessment of NIR-triggered PEG-coated NaGdF4:Tm3+/Yb3+bio-compatible upconversion nanoparticles for contrast enhancement in OCT imaging and optical thermometry.
In this investigation, we embarked on the synthesis of polyethylene glycol coated NaGdF4:Tm3+/Yb3+upconversion nanoparticles (UCNPs), aiming to assess their utility in enhancing image contrast within the context of swept source optical coherence tomography (OCT) and photo-thermal OCT imaging. Our research unveiled the remarkable UC emissions stemming from the transitions of Tm3+ions, specifically the1G4→3H6transitions, yielding vibrant blue emissions at 472 nm. We delved further into the UC mechanism, meticulously scrutinizing decay times and the nanoparticles' capacity to convert radiation into heat. Notably, these nanoparticles exhibited an impressive photo-thermal conversion efficiency of 37.5%. Furthermore, our investigations into their bio-compatibility revealed a promising outcome, with more than 90% cell survival after 24 h of incubation with HeLa cells treated with UCNPs. The nanoparticles demonstrated a notable thermal sensitivity of 4.7 × 10-3K-1at 300 K, signifying their potential for precise temperature monitoring at the cellular level.