斑马鱼和小鼠视网膜的缪勒神经胶质细胞再生

IF 8.7 1区 生物学 Q1 GENETICS & HEREDITY Annual review of genetics Pub Date : 2024-06-14 DOI:10.1146/annurev-genet-111523-102000
Jonathan Jui, Daniel Goldman
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引用次数: 0

摘要

视力是我们最宝贵的感官之一。人们对失去视力的恐惧超过其他任何残疾。因此,让盲人重见光明是视觉科学家的一个重要目标。斑马鱼等可再生物种为研究视网膜再生的内源机制提供了一个系统。小鼠等非再生物种则为测试刺激视网膜再生的策略提供了一个系统。斑马鱼和小鼠视网膜再生的关键是Müller神经胶质细胞,这是一种可塑性细胞类型,适合多种再生策略。在这里,我们回顾了斑马鱼用于视网膜再生的细胞和分子机制,以及这些机制的应用和其他刺激小鼠视网膜再生的策略。虽然我们的重点是 Müller 胶质(MG),但也讨论了生态位成分及其对 MG 重编程的影响。
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Müller Glial Cell-Dependent Regeneration of the Retina in Zebrafish and Mice.

Sight is one of our most precious senses. People fear losing their sight more than any other disability. Thus, restoring sight to the blind is an important goal of vision scientists. Proregenerative species, such as zebrafish, provide a system for studying endogenous mechanisms underlying retina regeneration. Nonregenerative species, such as mice, provide a system for testing strategies for stimulating retina regeneration. Key to retina regeneration in zebrafish and mice is the Müller glial cell, a malleable cell type that is amenable to a variety of regenerative strategies. Here, we review cellular and molecular mechanisms used by zebrafish to regenerate a retina, as well as the application of these mechanisms, and other strategies to stimulate retina regeneration in mice. Although our focus is on Müller glia (MG), niche components and their impact on MG reprogramming are also discussed.

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来源期刊
Annual review of genetics
Annual review of genetics 生物-遗传学
CiteScore
18.30
自引率
0.90%
发文量
17
期刊介绍: The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.
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