从信号振荡到体节形成

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current Opinion in Systems Biology Pub Date : 2024-05-25 DOI:10.1016/j.coisb.2024.100520
Wilke H.M. Meijer, Katharina F. Sonnen
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引用次数: 0

摘要

脊椎动物胚胎的周期性分割或体节发生受动态信号通路网络的调控。信号梯度决定了形成体节的间距,而信号振荡(统称为体节时钟)则确保了体节的定时。由于分节钟是组织水平信号动态的典范,其机制和功能一直是许多研究的主题。最近,研究人员能够以前所未有的精度分析和量化这些信号动态,揭示了整个发育过程中相互联系的振荡和全组织动态的复杂性。初步研究表明,信号动力学和细胞力学之间的相互作用如何驱动节段的周期性形成。展望未来,基于体外干细胞的(人类)胚胎发育模型等新技术将使体节发生机制的详细研究成为可能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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From signalling oscillations to somite formation

Periodic segmentation of vertebrate embryos or somitogenesis is regulated by a dynamic network of signalling pathways. Signalling gradients determine the spacing of the forming segments, while signalling oscillations, collectively termed the segmentation clock, ensure their regular timing. Since the segmentation clock is a paradigm of signalling dynamics at tissue level, its mechanism and function have been the topic of many studies. Recently, researchers have been able to analyse and quantify these signalling dynamics with unprecedented precision, revealing the complexity of interlinked oscillations and tissue-wide dynamics throughout development. Initial studies have shown how the interplay between signalling dynamics and cellular mechanics drive the periodic formation of segments. Looking ahead, new techniques such as in vitro stem cell-based models of (human) embryonic development will enable detailed investigations into the mechanisms of somitogenesis.

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来源期刊
Current Opinion in Systems Biology
Current Opinion in Systems Biology Mathematics-Applied Mathematics
CiteScore
7.10
自引率
2.70%
发文量
20
期刊介绍: Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
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