{"title":"从信号振荡到体节形成","authors":"Wilke H.M. Meijer, Katharina F. Sonnen","doi":"10.1016/j.coisb.2024.100520","DOIUrl":null,"url":null,"abstract":"<div><p>Periodic segmentation of vertebrate embryos or somitogenesis is regulated by a dynamic network of signalling pathways. Signalling gradients determine the spacing of the forming segments, while signalling oscillations, collectively termed the segmentation clock, ensure their regular timing. Since the segmentation clock is a paradigm of signalling dynamics at tissue level, its mechanism and function have been the topic of many studies. Recently, researchers have been able to analyse and quantify these signalling dynamics with unprecedented precision, revealing the complexity of interlinked oscillations and tissue-wide dynamics throughout development. Initial studies have shown how the interplay between signalling dynamics and cellular mechanics drive the periodic formation of segments. Looking ahead, new techniques such as <em>in vitro</em> stem cell-based models of (human) embryonic development will enable detailed investigations into the mechanisms of somitogenesis.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310024000167/pdfft?md5=420768ab4b5e9d9250762433dd41de5a&pid=1-s2.0-S2452310024000167-main.pdf","citationCount":"0","resultStr":"{\"title\":\"From signalling oscillations to somite formation\",\"authors\":\"Wilke H.M. Meijer, Katharina F. Sonnen\",\"doi\":\"10.1016/j.coisb.2024.100520\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Periodic segmentation of vertebrate embryos or somitogenesis is regulated by a dynamic network of signalling pathways. Signalling gradients determine the spacing of the forming segments, while signalling oscillations, collectively termed the segmentation clock, ensure their regular timing. Since the segmentation clock is a paradigm of signalling dynamics at tissue level, its mechanism and function have been the topic of many studies. Recently, researchers have been able to analyse and quantify these signalling dynamics with unprecedented precision, revealing the complexity of interlinked oscillations and tissue-wide dynamics throughout development. Initial studies have shown how the interplay between signalling dynamics and cellular mechanics drive the periodic formation of segments. Looking ahead, new techniques such as <em>in vitro</em> stem cell-based models of (human) embryonic development will enable detailed investigations into the mechanisms of somitogenesis.</p></div>\",\"PeriodicalId\":37400,\"journal\":{\"name\":\"Current Opinion in Systems Biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-05-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2452310024000167/pdfft?md5=420768ab4b5e9d9250762433dd41de5a&pid=1-s2.0-S2452310024000167-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Systems Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2452310024000167\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452310024000167","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Periodic segmentation of vertebrate embryos or somitogenesis is regulated by a dynamic network of signalling pathways. Signalling gradients determine the spacing of the forming segments, while signalling oscillations, collectively termed the segmentation clock, ensure their regular timing. Since the segmentation clock is a paradigm of signalling dynamics at tissue level, its mechanism and function have been the topic of many studies. Recently, researchers have been able to analyse and quantify these signalling dynamics with unprecedented precision, revealing the complexity of interlinked oscillations and tissue-wide dynamics throughout development. Initial studies have shown how the interplay between signalling dynamics and cellular mechanics drive the periodic formation of segments. Looking ahead, new techniques such as in vitro stem cell-based models of (human) embryonic development will enable detailed investigations into the mechanisms of somitogenesis.
期刊介绍:
Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution