运动诱发的炎症会改变对情感互动的感知和视觉探索

IF 3.7 Q2 IMMUNOLOGY Brain, behavior, & immunity - health Pub Date : 2024-06-11 DOI:10.1016/j.bbih.2024.100806
Johannes Keck , Celine Honekamp , Kristina Gebhardt , Svenja Nolte , Marcel Linka , Benjamin de Haas , Jörn Munzert , Karsten Krüger , Britta Krüger
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引用次数: 0

摘要

方法19名年龄在19至33岁之间的男性健康成年人在跑步机上以70%的最大氧饱和度进行了45分钟的下坡跑,以诱导最大肌动素血液升高,从而导致促炎状态。选择了两种对照条件:无下坡的对照跑和不进行体育锻炼的休息条件。每次运动前(T0)、运动后(T1)、运动后 3 小时(T3)和运动后 24 小时(T24)均采集血液样本,用于分析炎症反应。运动后 3 小时,受试者观察点光源显示屏(PLDs)上描绘的四种情绪(快乐、亲切、悲伤和愤怒)的人际互动。参与者对情绪内容进行分类,评估刺激物的情绪强度,并对自己的评级表示信心。结果与对照组相比,下坡运动条件导致测量的细胞因子(IL6、CRP、MCP-1)和肌肉损伤标志物(肌红蛋白)显著升高,表明下坡跑后出现了促炎状态。下坡跑后,情绪识别率明显降低,而对照组跑步后则无此影响。参与者对特定情绪线索的敏感度也有所下降。然而,下坡跑对感知到的情绪强度或对给定评级的主观信心没有影响。下坡跑后,参与者的视觉扫描行为受到了影响,他们更多地将注意力集中在悲伤的刺激物上,而在对照组条件下,参与者在观察快乐的刺激物时则表现出更多的注意力集中。具体来说,炎症会导致对社会交往中情绪内容的识别率下降,这归因于所有情绪类别的辨别能力减弱。此外,我们还观察到了视觉探索行为的改变。这证实了炎症会严重影响个体对社交和情感刺激的反应能力。
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Exercise-induced inflammation alters the perception and visual exploration of emotional interactions

Introduction

The study aimed to investigate whether an exercise-induced pro-inflammatory response alters the perception as well as visual exploration of emotional body language in social interactions.

Methods

In a within-subject design, 19 male, healthy adults aged between 19 and 33 years performed a downhill run for 45 min at 70% of their VO2max on a treadmill to induce maximal myokine blood elevations, leading to a pro-inflammatory status. Two control conditions were selected: a control run with no decline and a rest condition without physical exercise. Blood samples were taken before (T0), directly after (T1), 3 h after (T3), and 24 h after (T24) each exercise for analyzing the inflammatory response. 3 h after exercise, participants observed point-light displays (PLDs) of human interactions portraying four emotions (happiness, affection, sadness, and anger). Participants categorized the emotional content, assessed the emotional intensity of the stimuli, and indicated their confidence in their ratings. Eye movements during the entire paradigm and self-reported current mood were also recorded.

Results

The downhill exercise condition resulted in significant elevations of measured cytokines (IL6, CRP, MCP-1) and markers for muscle damage (Myoglobin) compared to the control running condition, indicating a pro-inflammatory state after the downhill run. Emotion recognition rates decreased significantly after the downhill run, whereas no such effect was observed after control running. Participants' sensitivity to emotion-specific cues also declined. However, the downhill run had no effect on the perceived emotional intensity or the subjective confidence in the given ratings. Visual scanning behavior was affected after the downhill run, with participants fixating more on sad stimuli, in contrast to the control conditions, where participants exhibited more fixations while observing happy stimuli.

Conclusion

Our study demonstrates that inflammation, induced through a downhill running model, impairs perception and emotional recognition abilities. Specifically, inflammation leads to decreased recognition rates of emotional content of social interactions, attributable to diminished discrimination capabilities across all emotional categories. Additionally, we observed alterations in visual exploration behavior. This confirms that inflammation significantly affects an individual's responsiveness to social and affective stimuli.

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来源期刊
Brain, behavior, & immunity - health
Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience
CiteScore
8.50
自引率
0.00%
发文量
0
审稿时长
97 days
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