UFMylation:调节蛋白稳态和细胞功能不可或缺的翻译后修饰。

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacology & Therapeutics Pub Date : 2024-06-13 DOI:10.1016/j.pharmthera.2024.108680
Xiaohui Wang , Xiaowei Lv , Jingjing Ma , Guoqiang Xu
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引用次数: 0

摘要

泛素折叠修饰因子 1(UBiquitin-fold modifier 1,UFM1)通过一系列酶促反应与蛋白质底物共价结合,这一过程被称为 UFMylation。UFMylation 协调一系列重要的生物功能,包括维持内质网(ER)平衡、促进蛋白质生物生成、促进细胞分化、调节 DNA 损伤反应以及参与癌症相关信号通路。在过去的几年中,超频分化已迅速发展成为最前沿的研究领域之一,但仍有许多问题有待揭示。在这篇综述中,首先简要介绍了 UFMylation 及其与疾病相关的细胞功能。然后,我们总结了鉴定 UFMylation 底物的蛋白质组学方法,并探讨了 UFMylation 对基因转录、蛋白质翻译和维持 ER 平衡的影响。接下来,我们强调了 UFMylation 与两种蛋白质降解途径(泛素-蛋白酶体系统和自噬-溶酶体途径)之间错综复杂的调控关系,并探讨了其作为药物靶点的潜力。最后,我们讨论了 UFMylation 领域的新观点。本综述可为针对 UFMylation 系统的药物发现提供有价值的见解。
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UFMylation: An integral post-translational modification for the regulation of proteostasis and cellular functions

Ubiquitin-fold modifier 1 (UFM1) is covalently conjugated to protein substrates via a cascade of enzymatic reactions, a process known as UFMylation. UFMylation orchestrates an array of vital biological functions, including maintaining endoplasmic reticulum (ER) homeostasis, facilitating protein biogenesis, promoting cellular differentiation, regulating DNA damage response, and participating in cancer-associated signaling pathways. UFMylation has rapidly evolved into one of the forefront research areas within the last few years, yet much remains to be uncovered. In this review, first, UFMylation and its cellular functions associated with diseases are briefly introduced. Then, we summarize the proteomic approaches for identifying UFMylation substrates and explore the impact of UFMylation on gene transcription, protein translation, and maintenance of ER homeostasis. Next, we highlight the intricate regulation between UFMylation and two protein degradation pathways, the ubiquitin-proteasome system and the autophagy-lysosome pathway, and explore the potential of UFMylation system as a drug target. Finally, we discuss emerging perspectives in the UFMylation field. This review may provide valuable insights for drug discovery targeting the UFMylation system.

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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
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