Yuan-Yuan Geng, Shuo Yang, Zhi-Hao Liu, Si-Yu Wang, Pan Ge
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引用次数: 0
摘要
目的：胃癌是全世界发病率和死亡率都很高的恶性肿瘤。由于预后差、生存率低，胃癌的治疗受到广泛关注。肉桂醛（CA）是中药肉桂的主要单一活性成分，具有多种药理作用。CA 对某些肿瘤细胞生长的抑制作用已被证实，但其对胃癌的治疗作用却鲜有报道：方法：通过网络药理学、生物信息学方法和分子对接技术，我们预测了 CA 与胃癌的相互作用靶点。方法：通过网络药理学方法和生物信息学方法以及分子对接技术，我们预测了 CA 与胃癌的相互作用靶点，并发现凋亡是 CA 对胃癌细胞的重要作用方式。随后，我们在体外培养的胃癌细胞系中进行了验证：结果表明，在CA的作用下，Jak2/Stat3通路受到抑制，Bcl-2/Bax比值下降，胃癌细胞的凋亡呈浓度依赖性：总之，CA可通过抑制Jak2/Stat3通路的活性来促进胃癌细胞的凋亡，从而达到治疗胃癌的效果。
Cinnamaldehyde Regulates the Migration and Apoptosis of Gastric Cancer Cells by Inhibiting the Jak2/Stat3 Pathway.
Objective: Gastric cancer is a malignant tumor with high morbidity and mortality all around the world. Because of its poor prognosis and low survival rate, the treatment of gastric cancer has received extensive attention. Cinnamaldehyde (CA) is the main single active component of the Chinese herbal medicine cinnamon, which has a variety of pharmacological effects. The inhibitory effect of CA on the growth of some tumor cells has been proven, but its therapeutic effect on gastric cancer has rarely been reported.
Methods: Through network pharmacology, bioinformatics methods, and molecular docking technology, we predicted the interaction targets of CA and gastric cancer. Moreover, we found that apoptosis is an important mode of action of CA on gastric cancer cells. Subsequently, we validated it in gastric cancer cell lines cultured in vitro.
Results: The results showed that in the presence of CA, the Jak2/Stat3 pathway was inhibited, the ratio of Bcl-2/Bax decreased, and the apoptosis of gastric cancer cells was promoted in a concentration-dependent.
Conclusion: In conclusion, CA can promote the apoptosis of gastric cancer cells by inhibiting the activity of the Jak2/Stat3 pathway, which may achieve the effect of treating gastric cancer.
期刊介绍：
Digestive Diseases and Sciences publishes high-quality, peer-reviewed, original papers addressing aspects of basic/translational and clinical research in gastroenterology, hepatology, and related fields. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and clinical breakthroughs; insights from prominent academicians and practitioners concerning new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and worldwide social, economic, and governmental policies that affect the delivery of care within the disciplines of gastroenterology and hepatology.
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