David Calderón-Rangel, Ángel Rentería-Gómez, Alicia E. Cruz-Jiménez, Manuel A. Rentería Gómez, J. Oscar C. Jiménez-Halla and Rocío Gámez-Montaño
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引用次数: 0
摘要
通过基于异氰酸酯的多组分反应(IMCR)合成了一系列连接型 1,5-二取代四唑(1,5-DS-Ts),并以此为合成平台,在绿色条件下获得了含有环氧异吲哚-1(6H)-酮支架的结合型多杂环。这种快速声化学合成策略包括一个双多米诺过程,在乌基叠氮(UA)反应中使用一个正交杂环输入。通过 DFT 计算和 NBO 分析,我们了解了 UA 机理中 1,5 电环化所涉及的假环反应。
Ultrasound-assisted diastereoselective green synthesis of spiro-fused-γ-lactams functionalized with an amide bond heterocyclic bioisostere via the Ugi azide/domino process coupled strategy†
A series of linked-type 1,5-disubstituted tetrazoles (1,5-DS-Ts) were synthesised via an isocyanide-based multicomponent reaction (IMCR) and used as synthetic platforms to access bound-type polyheterocycles containing an epoxyisoindol-1(6H)-one scaffold under green conditions. This rapid sonochemical synthetic strategy includes a double domino process using an orthogonal heterocyclic input in the Ugi-azide (UA) reaction. DFT calculations and NBO analysis were performed to understand the pseudopericyclic reaction involved in the 1,5-electrocyclization of the UA mechanism.