肌肉骨骼结缔组织钟的运动诱导。

IF 5 2区 生物学 Q2 CELL BIOLOGY American journal of physiology. Cell physiology Pub Date : 2024-08-01 Epub Date: 2024-06-17 DOI:10.1152/ajpcell.00285.2024
Danielle Steffen, Michael Kjaer, Ching-Yan Chloé Yeung
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引用次数: 0

摘要

肌肉骨骼系统对于运动和支撑至关重要,它依赖于结缔组织平衡的微妙平衡。保持这种平衡对组织的健康和功能至关重要。近十年来,越来越多的证据表明,昼夜节律钟是几种结缔组织时钟中细胞外基质(ECM)平衡的主要调节器。最近,运动已成为软骨和椎间盘昼夜节律的重要调节因素。了解运动对结缔组织外周时钟的影响,有助于增强组织健康和预防疾病。运动引起的热量、糖皮质激素释放、机械负荷和组织间串扰等因素可能在控制结缔组织昼夜节律方面发挥关键作用。这篇微型综述强调了阐明运动影响结缔组织昼夜节律的机制以优化 ECM 平衡的重要性。利用运动作为结缔组织昼夜节律的调节器,可为体育训练提供新的治疗方法,以预防肌肉骨骼疾病并促进康复。
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Exercise entrainment of musculoskeletal connective tissue clocks.

The musculoskeletal system, crucial for movement and support, relies on the delicate balance of connective tissue homeostasis. Maintaining this equilibrium is essential for tissue health and function. There has been increasing evidence in the past decade that shows the circadian clock as a master regulator of extracellular matrix (ECM) homeostasis in several connective tissue clocks. Very recently, exercise has emerged as a significant entrainment factor for cartilage and intervertebral disk circadian rhythms. Understanding the implications of exercise on connective tissue peripheral clocks holds promise for enhancing tissue health and disease prevention. Exercise-induced factors such as heat, glucocorticoid release, mechanical loading, and inter-tissue cross talk may play pivotal roles in entraining the circadian rhythm of connective tissues. This mini review underscores the importance of elucidating the mechanisms through which exercise influences circadian rhythms in connective tissues to optimize ECM homeostasis. Leveraging exercise as a modulator of circadian rhythms in connective tissues may offer novel therapeutic approaches to physical training for preventing musculoskeletal disorders and enhancing recovery.

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来源期刊
CiteScore
9.10
自引率
1.80%
发文量
252
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Cell Physiology is dedicated to innovative approaches to the study of cell and molecular physiology. Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly. Manuscripts dealing with the structure and function of cell membranes, contractile systems, cellular organelles, and membrane channels, transporters, and pumps are encouraged. Studies dealing with integrated regulation of cellular function, including mechanisms of signal transduction, development, gene expression, cell-to-cell interactions, and the cell physiology of pathophysiological states, are also eagerly sought. Interdisciplinary studies that apply the approaches of biochemistry, biophysics, molecular biology, morphology, and immunology to the determination of new principles in cell physiology are especially welcome.
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