全面概述白色念珠菌:一种新出现的耐多药真菌病原体。

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of microbiology and biotechnology Pub Date : 2024-07-28 Epub Date: 2024-06-15 DOI:10.4014/jmb.2404.04040
Ji-Seok Kim, Hyunjin Cha, Yong-Sun Bahn
{"title":"全面概述白色念珠菌:一种新出现的耐多药真菌病原体。","authors":"Ji-Seok Kim, Hyunjin Cha, Yong-Sun Bahn","doi":"10.4014/jmb.2404.04040","DOIUrl":null,"url":null,"abstract":"<p><p>The rise of <i>Candida auris</i>, a multidrug-resistant fungal pathogen, across more than 40 countries, has signaled an alarming threat to global health due to its significant resistance to existing antifungal therapies. Characterized by its rapid spread and robust drug resistance, <i>C. auris</i> presents a critical challenge in managing infections, particularly in healthcare settings. With research on its biological traits and genetic basis of virulence and resistance still in the early stages, there is a pressing need for a concerted effort to understand and counteract this pathogen. This review synthesizes current knowledge on the epidemiology, biology, genetic manipulation, pathogenicity, diagnostics, and resistance mechanisms of <i>C. auris</i>, and discusses future directions in research and therapeutic development. By exploring the complexities surrounding <i>C. auris</i>, we aim to underscore the importance of advancing research to devise effective control and treatment strategies.</p>","PeriodicalId":16481,"journal":{"name":"Journal of microbiology and biotechnology","volume":"34 7","pages":"1365-1375"},"PeriodicalIF":2.5000,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11294645/pdf/","citationCount":"0","resultStr":"{\"title\":\"Comprehensive Overview of <i>Candida auris</i>: An Emerging Multidrug-Resistant Fungal Pathogen.\",\"authors\":\"Ji-Seok Kim, Hyunjin Cha, Yong-Sun Bahn\",\"doi\":\"10.4014/jmb.2404.04040\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The rise of <i>Candida auris</i>, a multidrug-resistant fungal pathogen, across more than 40 countries, has signaled an alarming threat to global health due to its significant resistance to existing antifungal therapies. Characterized by its rapid spread and robust drug resistance, <i>C. auris</i> presents a critical challenge in managing infections, particularly in healthcare settings. With research on its biological traits and genetic basis of virulence and resistance still in the early stages, there is a pressing need for a concerted effort to understand and counteract this pathogen. This review synthesizes current knowledge on the epidemiology, biology, genetic manipulation, pathogenicity, diagnostics, and resistance mechanisms of <i>C. auris</i>, and discusses future directions in research and therapeutic development. By exploring the complexities surrounding <i>C. auris</i>, we aim to underscore the importance of advancing research to devise effective control and treatment strategies.</p>\",\"PeriodicalId\":16481,\"journal\":{\"name\":\"Journal of microbiology and biotechnology\",\"volume\":\"34 7\",\"pages\":\"1365-1375\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11294645/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of microbiology and biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.4014/jmb.2404.04040\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of microbiology and biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.4014/jmb.2404.04040","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/15 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

由于对现有抗真菌疗法产生严重耐药性,耐多药真菌病原体白色念珠菌在 40 多个国家中的崛起对全球健康构成了令人担忧的威胁。这种真菌具有传播迅速和耐药性强的特点,给管理感染,尤其是医疗机构的感染带来了严峻的挑战。由于对其生物特性以及毒力和耐药性遗传基础的研究仍处于早期阶段,因此迫切需要各方共同努力来了解和应对这种病原体。这篇综述综合了目前关于 C. auris 的流行病学、生物学、基因操作、致病性、诊断和抗药性机制的知识,并讨论了未来的研究和治疗开发方向。通过探讨 C. auris 的复杂性,我们旨在强调推进研究以制定有效控制和治疗策略的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Comprehensive Overview of Candida auris: An Emerging Multidrug-Resistant Fungal Pathogen.

The rise of Candida auris, a multidrug-resistant fungal pathogen, across more than 40 countries, has signaled an alarming threat to global health due to its significant resistance to existing antifungal therapies. Characterized by its rapid spread and robust drug resistance, C. auris presents a critical challenge in managing infections, particularly in healthcare settings. With research on its biological traits and genetic basis of virulence and resistance still in the early stages, there is a pressing need for a concerted effort to understand and counteract this pathogen. This review synthesizes current knowledge on the epidemiology, biology, genetic manipulation, pathogenicity, diagnostics, and resistance mechanisms of C. auris, and discusses future directions in research and therapeutic development. By exploring the complexities surrounding C. auris, we aim to underscore the importance of advancing research to devise effective control and treatment strategies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of microbiology and biotechnology
Journal of microbiology and biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MICROBIOLOGY
CiteScore
5.50
自引率
3.60%
发文量
151
审稿时长
2 months
期刊介绍: The Journal of Microbiology and Biotechnology (JMB) is a monthly international journal devoted to the advancement and dissemination of scientific knowledge pertaining to microbiology, biotechnology, and related academic disciplines. It covers various scientific and technological aspects of Molecular and Cellular Microbiology, Environmental Microbiology and Biotechnology, Food Biotechnology, and Biotechnology and Bioengineering (subcategories are listed below). Launched in March 1991, the JMB is published by the Korean Society for Microbiology and Biotechnology (KMB) and distributed worldwide.
期刊最新文献
Loss in Pluripotency Markers in Mesenchymal Stem Cells upon Infection with Chlamydia trachomatis. A Comprehensive Review of Naringenin, a Promising Phytochemical with Therapeutic Potential. Anti-Inflammatory Activity of Biotransformed Platycodon grandiflorum Root Extracts Containing 3-O-β-D-Glucopyranosyl Platycosides in LPS-Stimulated Alveolar Macrophages, NR8383 Cells. Green Tea Attenuates the Particulate Matter (PM)2.5-Exposed Gut-Brain Axis Dysfunction through Regulation of Intestinal Microenvironment and Hormonal Changes. ELF3 Overexpression Contributes to the Malignant Transformation of HPV16 E6/ E7-Immortalized Keratinocytes by Promoting CCNE2 Expression.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1