马匹骨科疾病中氯膦酸的检测时间。

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY Journal of veterinary pharmacology and therapeutics Pub Date : 2024-06-16 DOI:10.1111/jvp.13453
Beatriz Seguí Pedrosa, Chris Dujardin, Ben Moses, Caryn Thompson, Patxi Sarasola, Florence Gattacceca, Benoit Loup, Patrice Garcia, Marie-Agnès Popot, Ludovic Bailly-Chouriberry
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引用次数: 0

摘要

氯屈膦酸被国际马术运动联合会指定为比赛用马的管制药物,而且根据国际赛马管理机构联合会的规定,3.5岁以下或赛前30天内的赛马不得服用氯屈膦酸。在这项研究中,35 匹参加比赛的赛马接受了单剂量 1.53 毫克氯屈膦酸/千克体重的肌肉注射治疗。在治疗前和用药后 10、20、30 和 40 天采集血浆样本。氯屈膦酸浓度的测定采用了一种经过验证的方法,并使用非线性混合效应模型对数据进行了拟合。氯屈膦酸的估计消耗半衰期为 10.6 天(个体间差异:17.9%)。年龄、体重、性别、疾病严重程度、剂量、训练天数、训练和比赛对消耗半衰期没有显著影响。通过模拟预测,氯屈膦酸浓度低于检测定量限 1.0 纳克/毫升的马匹比例在第 30 天为 93.9%,在第 40 天为 99.4%。这项研究为马术联合会和赛马管理机构提供了可靠地确定氯屈膦酸检测时间的依据,有助于马兽医为其照料的马匹建议比赛停药时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Detection times of clodronic acid in horses with orthopedic disease

Clodronic acid is designated as a controlled medication for competition horses by the International Federation for Equestrian Sports and, according to the International Federation of Horseracing Authorities, clodronic acid is not to be administered to racehorses younger than 3.5 years or within 30 days prior to a race. In this study, 35 horses involved in competition were treated with a single dose of 1.53 mg clodronic acid/kg bodyweight intramuscularly. Plasma samples were obtained before treatment and 10, 20, 30, and 40 days post-administration. Clodronic acid concentrations were measured using a validated method, and the data were fitted using a nonlinear mixed effects model. The estimated depletion half-life of clodronic acid was 10.6 days (inter-individual variability: 17.9%). Age, body weight, sex, disease severity, dose, training days, training, and competition did not significantly impact the depletion half-life. The percentage of horses predicted via simulation to have clodronic acid concentrations below the assay's limit of quantification of 1.0 ng/mL was 93.9% at day 30 and 99.4% at Day 40. This study provides rationale to the equestrian federations and horse racing authorities to reliably establish a detection time for clodronic acid, assisting equine veterinarians in recommending a competition withdrawal time for the horses under their care.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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