用于感染性糖尿病伤口愈合的单宁酸和硅酸盐功能化聚乙烯醇-透明质酸水凝胶。

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Regenerative Biomaterials Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI:10.1093/rb/rbae053
Zhentian Diao, Longkang Li, Huan Zhou, Lei Yang
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引用次数: 0

摘要

由于严重的炎症微环境、细菌感染和血管形成不良等并发症,慢性糖尿病伤口的愈合具有挑战性。本研究开发了一种新型可注射聚乙烯醇-透明质酸基复合水凝胶,通过单宁酸(TA)和硅酸盐官能化来制造 "一体化 "水凝胶 PTKH。一方面,将水凝胶局部注入伤口部位后,水凝胶会在原位逐渐发生溶胶-凝胶转变,从而形成一种具有粘合性和保护性的伤口敷料。通过调节水凝胶中 TA 和硅酸盐的含量,可以控制 PTKH 的流变特性、机械性能和膨胀能力。另一方面,PTKH 能够消除活性氧的过度表达、抗感染,并在体外为伤口愈合加速创造一个有利于细胞生长的微环境。随后的动物实验证明,PTKH 能极大地刺激血管生成和上皮化,同时减少炎症和感染风险。因此,考虑到其令人印象深刻的体外和体内结果,这种 "一体化 "多功能水凝胶有望用于慢性糖尿病伤口治疗。
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Tannic acid and silicate-functionalized polyvinyl alcohol-hyaluronic acid hydrogel for infected diabetic wound healing.

Healing of chronic diabetic wounds is challenging due to complications of severe inflammatory microenvironment, bacterial infection and poor vascular formation. Herein, a novel injectable polyvinyl alcohol-hyaluronic acid-based composite hydrogel was developed, with tannic acid (TA) and silicate functionalization to fabricate an 'all-in-one' hydrogel PTKH. On one hand, after being locally injected into the wound site, the hydrogel underwent a gradual sol-gel transition in situ, forming an adhesive and protective dressing for the wound. Manipulations of rheological characteristics, mechanical properties and swelling ability of PTKH could be performed via regulating TA and silicate content in hydrogel. On the other hand, PTKH was capable of eliminating reactive oxygen species overexpression, combating infection and generating a cell-favored microenvironment for wound healing acceleration in vitro. Subsequent animal studies demonstrated that PTKH could greatly stimulate angiogenesis and epithelization, accompanied with inflammation and infection risk reduction. Therefore, in consideration of its impressive in vitro and in vivo outcomes, this 'all-in-one' multifunctional hydrogel may hold promise for chronic diabetic wound treatment.

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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
期刊最新文献
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