癌症治疗中的肿瘤治疗场：细胞和分子机制的进步。

IF 2.8 3区医学 Q2 ONCOLOGY Clinical & Translational Oncology Pub Date : 2025-01-01 Epub Date: 2024-06-17 DOI:10.1007/s12094-024-03551-z

Tong Xiao, Hao Zheng, Kaiyang Zu, Youjia Yue, Ying Wang

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摘要

肿瘤治疗场（TTFields）利用中频和低强度电场抑制肿瘤细胞。然而，人们对其机制仍不甚了解。本文回顾了其在细胞和分子水平上的主要抗肿瘤机制，包括抑制增殖、诱导死亡、干扰迁移和激活免疫系统。文章还总结了与其他癌症治疗方法联合使用时的多方面生物效应。对其机理的深入了解将有助于开发更多潜在的抗肿瘤疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tumor-treating fields in cancer therapy: advances of cellular and molecular mechanisms.

Tumor-Treating Fields (TTFields) use intermediate-frequency and low-intensity electric fields to inhibit tumor cells. However, their mechanisms are still not well understood. This article reviews their key antitumor mechanisms at the cellular and molecular levels, including inhibition of proliferation, induction of death, disturbance of migration, and activation of the immune system. The multifaceted biological effects in combination with other cancer treatments are also summarized. The deep insight into their mechanism will help develop more potential antitumor treatments.

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来源期刊

Clinical & Translational Oncology 医学-肿瘤学

CiteScore

6.20

自引率

2.90%

发文量

240

审稿时长

1 months

期刊介绍： Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.