1-Thiosugars：从合成到应用

IF 18 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-14 DOI:10.2174/0113852728314452240524112438

Surabhi Gupta, Charles Gauthier

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引用次数: 0

摘要

1 硫代糖及其糖苷在碳水化合物化学中发挥着至关重要的作用，这主要是由于它们具有模仿 O 型糖苷的易用性和潜力。硫代糖苷的合成方法一直是个难题。近年来，研究人员对探索硫代糖苷在各个领域的应用表现出越来越浓厚的兴趣，包括开发天然产物衍生物、寡糖和多糖仿生、金属药物和树枝状聚合物。硫代糖合成的方法和方案层出不穷。本综述旨在全面介绍硫代糖的制备及其作为合成前体的应用。

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1-Thiosugars: From Synthesis to Applications

1-Thiosugars and their glycosides play crucial roles in carbohydrate chemistry, primarily due to their stability and potential for mimicking O-glycosides. The synthetic methodologies for thioglycosides pose ongoing challenges. In recent years, researchers have shown a growing interest in exploring the applications of thiosugars in various fields, including the development of natural product derivatives, oligo- and polysaccharide mimics, metallodrugs, and dendrimers. Numerous approaches and protocols have been devised for the synthesis of thiosugars. This review aims to comprehensively cover the efforts towards preparing thiosugars and their application as synthetic precursors.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.