新兴水凝胶微型/纳米机器人的设计与运动可控性

Yang Liu, Ying Feng, Linlin Liu, Miao An, Huaming Yang
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摘要

微型/纳米机器人(MNRs)因其不受约束的特性和足够小的尺寸可通过许多微小的环境,在生物医学应用中大有可为。然而,由于低雷诺数环境和粒子的布朗运动,MNRs 在液体环境中的高效运动仍是一项挑战。在此,我们设计了带有水凝胶负载磁性颗粒的新兴 MNR。所提出的水凝胶 MNRs(HMNRs)具有生物相容性和可控性。HMNRs 的运动可控性是通过施加振荡磁场和定制磁场实现的。实验证明,由振荡磁场驱动的 HMNR 蜂群比由磁性颗粒组成的 MNR 蜂群表现出更快的运动速度。在定制磁场的控制下,HMNR 在复杂管道中的运动表现出精确的可控性。这种方法为生物应用中 HMNR 的一般生产提供了一种更加良性的方法。
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Design and Motion Controllability of Emerging Hydrogel Micro/Nanorobots
Micro/nanorobots (MNRs) are promising for biomedical applications due to their unconstrained nature and small enough size to pass through many tiny environments. However, the efficient movement of MNRs in liquid environments is still a challenge due to the low Reynolds number environment and the Brownian motion of particles. Herein, emerging MNRs with hydrogel‐loaded magnetic particles are designed. The proposed hydrogel MNRs (HMNRs) exhibit biocompatible and controllable characteristics. The motion controllability of HMNRs is realized by applying oscillating magnetic field and customized magnetic field. Experimentally, it is demonstrated that the HMNR swarms driven by the oscillating magnetic field exhibit a faster motion speed than the MNR swarms composed of magnetic particles. The HMNRs show precise controllability of the movement in the complex pipeline under the control of customized magnetic field. This method can offer a more benign approach to the general production of HMNRs for biological applications.
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