用于动态组织修复的扩散诱导相分离三维打印支架

BMEMat Pub Date : 2024-06-12 DOI:10.1002/bmm2.12108
Muyuan Chai, Wenwen Zhong, Shengtao Yan, Tan Ye, Rui Zheng, Zhilu Yang, Xuetao Shi
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摘要

许多氢键交联水凝胶具有独特的性能,但其有限的可加工性阻碍了它们的潜在应用。通过在这些水凝胶中加入氢键解离剂(HBD),我们开发出了可注射的三维打印油墨,称为扩散诱导相分离(DIPS)三维打印油墨。在挤入水中并随后扩散 HBD 后,这些油墨会迅速固化。由于氢键的再生,DIPS 打印的支架保留了大部分原有的水凝胶特性。此外,氢键的可逆性使 DIPS 三维打印支架具有卓越的回收和再打印能力,从而减少了宝贵的油墨原料或添加剂的浪费。后处理引入了新的交联方法,可在很大范围内调节 DIPS 支架的机械性能和降解特性。基于其合适的机械性能和生物活性,我们利用 DIPS 支架在兔子模型中成功修复并重建了阴茎勃起组织的复杂缺损。总之,这种方法适用于各种氢键交联水凝胶,它们能提供温和的印刷条件,并能加入生物活性剂。它们可用作动态组织重建、可穿戴设备或软机器人的支架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Diffusion-induced phase separation 3D printed scaffolds for dynamic tissue repair

Many hydrogen-bonded cross-linked hydrogels possess unique properties, but their limited processability hinders their potential applications. By incorporating a hydrogen bond dissociator (HBD) into these hydrogels, we developed injectable 3D printing inks termed diffusion-induced phase separation (DIPS) 3D printing inks. Upon extrusion into water and subsequent diffusion of HBD, these ink cure rapidly. The DIPS-printed scaffold retained most of the original hydrogel properties due to the regeneration of hydrogen bonds. Additionally, the reversible nature of hydrogen bonds provides DIPS 3D-printed scaffolds with exceptional recycling and reprinting capabilities, resulting in a reduction in the waste of valuable raw ink materials or additives. Postprocessing introduces new crosslinking methods that modulate the mechanical properties and degradation characteristics of DIPS scaffolds over a broad range. Based on its suitable mechanical properties and bioactivity, we successfully repaired and functionally reconstructed a complex defect in penile erectile tissue using the DIPS scaffold in a rabbit model. In summary, this approach is relevant for various hydrogen-bonded cross-linked hydrogels that offer mild printing conditions and enable the incorporation of bioactive agents. They can be used as scaffolds for dynamic tissue reconstruction, wearable devices, or soft robots.

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