迟发性他克莫司诱发结肠炎伴粘膜延迟愈合：一份病例报告

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-06-11 DOI:10.1136/flgastro-2024-102714

Scott James Mcildowie, Antonia MD Churchhouse, Katie Robertson, Jonathan M Blackwell

{"title":"迟发性他克莫司诱发结肠炎伴粘膜延迟愈合：一份病例报告","authors":"Scott James Mcildowie, Antonia MD Churchhouse, Katie Robertson, Jonathan M Blackwell","doi":"10.1136/flgastro-2024-102714","DOIUrl":null,"url":null,"abstract":"Tacrolimus is a calcineurin inhibitor rarely associated with gastrointestinal injury and reported only a handful of times in the literature. We present a case report demonstrating late-onset colitis in a patient taking tacrolimus for years, with typical histological features, associated with delayed mucosal healing. We hope this highlights the potential variability in both presentation and resolution in cases of tacrolimus-induced colitis.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"10 10","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Late-onset tacrolimus-induced colitis associated with delayed mucosal healing: a case report\",\"authors\":\"Scott James Mcildowie, Antonia MD Churchhouse, Katie Robertson, Jonathan M Blackwell\",\"doi\":\"10.1136/flgastro-2024-102714\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Tacrolimus is a calcineurin inhibitor rarely associated with gastrointestinal injury and reported only a handful of times in the literature. We present a case report demonstrating late-onset colitis in a patient taking tacrolimus for years, with typical histological features, associated with delayed mucosal healing. We hope this highlights the potential variability in both presentation and resolution in cases of tacrolimus-induced colitis.\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":\"10 10\",\"pages\":\"\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/flgastro-2024-102714\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/flgastro-2024-102714","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

摘要

他克莫司（Tacrolimus）是一种钙神经蛋白抑制剂，很少与胃肠道损伤有关，在文献中仅有少量报道。我们提交的病例报告显示，一名服用他克莫司多年的患者出现了晚发性结肠炎，具有典型的组织学特征，并伴有粘膜愈合延迟。我们希望借此强调他克莫司诱发结肠炎病例在表现和缓解方面的潜在变异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Late-onset tacrolimus-induced colitis associated with delayed mucosal healing: a case report

Tacrolimus is a calcineurin inhibitor rarely associated with gastrointestinal injury and reported only a handful of times in the literature. We present a case report demonstrating late-onset colitis in a patient taking tacrolimus for years, with typical histological features, associated with delayed mucosal healing. We hope this highlights the potential variability in both presentation and resolution in cases of tacrolimus-induced colitis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.