Shiying Tang, Yixiao Deng, Yinan Yan, Jie Bai, Huiying He, Shudong Zhang, Jie Yang, Min Qiu, X. Tian
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引用次数: 0
摘要
我们报告了一例被诊断为肾透明细胞癌 III 期的 59 岁中国男性病例，他在随访 5 年后出现了两个可疑的肺部病变。病理评估发现了两种不同类型的癌症：肺原位腺癌和伴有肺转移的透明细胞肾癌。对肺组织样本进行了测序，测序组包括 1267 个癌症相关基因。分析结果显示，两种肺部病变的分子特征完全不同，而上舌叶和肾脏的克隆突变相似。这表明存在多个同步原发肿瘤。
Next-generation sequencing identifies the mutational signature of double primary and metastatic malignancies: A case report
We present the case of a 59-year-old Chinese man diagnosed with stage III clear cell renal cell carcinoma who developed 2 suspicious lung lesions 5 years after follow-up. Pathological evaluation revealed 2 distinct types of cancer: lung adenocarcinoma in situ and clear cell renal carcinoma with lung metastasis. Lung tissue samples were sequenced using a panel of 1267 cancer-related genes. The analysis revealed completely different molecular profiles between the 2 lung lesions and similar clonal mutations in the superior lingular lobe and kidney. This indicates multiple metachronous primary tumors.
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