原发性开角型青光眼与血清脂质之间的相关性

Jasiya Bashir
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引用次数: 0

摘要

背景:青光眼是全球致盲的主要原因之一,而眼压(IOP)是主要的风险因素。然而,即使眼压得到控制,一些青光眼病例仍会发展。这表明,其他风险因素也是导致青光眼发病的原因之一。我们的研究旨在确定原发性开角型青光眼(POAG)与血清脂质水平之间的相关性:本研究在斯利那加政府医学院眼科系进行,包括 50 名患有 POAG 的受试者和 50 名未患青光眼的对照受试者。所有受试者均接受了全面的眼科检查。测量空腹血脂概况,包括总胆固醇、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)和甘油三酯,并对两组进行比较:结果:POAG 组和对照组的血脂谱存在显著差异。我们发现 P 值小于 0.001,这表明具有统计学意义。虽然对照组的高密度脂蛋白水平较高,但这一差异在统计学上并不显著:结论:血脂谱参数的改变与 POAG 有独立的关联。高水平的血清胆固醇、甘油三酯和低密度脂蛋白与 POAG 显著相关。
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Correlation Between Primary Open Angle Glaucoma and Serum Lipids
Background: Glaucoma is one of the leading causes of blindness worldwide, with Intraocular Pressure (IOP) being the primary risk factor. However, some cases of glaucoma progress even with controlled IOP. This indicates that other risk factors also contribute to its pathogenesis. Our study aims to determine the correlation between Primary Open-Angle Glaucoma (POAG) and serum lipid levels. Material and Methods: This study was conducted in the Department of Ophthalmology at Government Medical College, Srinagar, including 50 subjects with POAG and 50 control subjects without glaucoma. All participants underwent a comprehensive ophthalmic examination. Fasting lipid profiles, including total cholesterol, Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL) and triglycerides, were measured and compared between the two groups. Results: Significant differences were observed in the lipid profiles between the POAG and control groups. We found a P value of < 0.001 which indicates statistical significance. While HDL levels were higher in the control group, this difference was not statistically significant. Conclusion: Altered lipid profile parameters are independently associated with POAG. High levels of serum cholesterol, triglycerides and LDL significantly correlate with POAG.
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