牙科和骨科钛植入物的混合涂层:当前的进展与挑战

BMEMat Pub Date : 2024-06-10 DOI:10.1002/bmm2.12105
Weilong Tang, Nicholas G. Fischer, Xinzi Kong, Ting Sang, Z. Ye
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引用次数: 0

摘要

牙科和骨科钛金属植入物已被成功广泛使用,但由于并发症导致的高治疗成本、高发病率甚至高死亡率,它们仍然面临着挑战。本综述重点介绍通过整合多种策略和材料来预防和减轻植入失败的混合涂层。首先讨论了制造和合成混合涂层的形式。然后,我们根据这些涂层的生物功能对其进行分类:抗菌涂层,对于预防难以治疗的感染至关重要;促进骨结合的涂层,对于种植体的机械稳定性至关重要;促进软组织附着的涂层,有助于种植体的整体成功和美观。我们总结了整合多种生物功能的多功能涂层的最新进展,这是减少种植并发症的另一种综合方法。文章最后讨论了该领域的未来发展方向,强调了这些生物功能混合涂层在患者身上取得商业成功的潜力和面临的显著挑战。总之,我们的文章全面概述了当前的发展情况,并对混合涂层的未来进行了展望,有望为牙科和整形外科植入物带来革命性的变化。
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Hybrid coatings on dental and orthopedic titanium implants: Current advances and challenges
Dental and orthopedic titanium implants are successfully and widely used but still face challenges due to complications leading to high treatment cost, morbidity, and even mortality. This review focuses on the hybrid coatings designed to prevent and mitigate implant failure by integrating multiple strategies and materials. The forms of manufacturing and synthesizing hybrid coatings were first discussed. We then categorize these coatings based on their biological functions: antibacterial coatings, which are essential for preventing difficult‐to‐treat infection; coatings designed to promote osseointegration, crucial for the mechanical stability of implants; coatings that encourage soft tissue attachment, contributing to the overall success and esthetics of implant. We summarize the state of the art in multifunctional coatings that integrate multiple biological functions as an alternative, holistic approach for reducing implant complications. The review culminates in a discussion on future directions in the field, emphasizing the potential and notable challenges these biofunctional hybrid coatings face toward obtaining commercial success in patients. Together, our article provides a comprehensive overview of current developments and a glimpse into the future of hybrid coatings for potentially revolutionizing dental and orthopedic implants.
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