萜烯的潜在治疗价值

Henry Lowe, Amza Ali, Blair Steele, Lorenzo Gordon, Justin Grant
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摘要

萜烯是由许多植物、果实、动物、昆虫和其他生物体产生的庞大而多样的天然挥发性次级代谢物的一部分。萜烯是天然代谢物中最大的一类,仅植物就能产生超过 55,000 种萜烯,主要以精油的形式存在。在人体中,它们具有重要的生物特性,如抗真菌、抗病毒、抗菌、消炎、抗寄生虫、降血糖、抗癌和镇痛。在植物中,萜烯还在针对食草动物和入侵植物的防御机制、抗病性、植物之间的化学信号传递和交流、防止光氧化、植物环境调解、热保护和吸引传粉昆虫等方面发挥重要作用。此外,萜烯还能产生植物的气味、口感、风味和色素,因此被用作香料和食品染料。萜烯还可用于生产合成聚合物、天然橡胶(聚异戊二烯)、有机溶剂、清漆、油墨、粘合剂、清洁产品、生物燃料、杀虫剂以及食品和饮料产品。因此,萜烯在现代医学、制药、营养保健品、化妆品和其他行业中具有重要价值。
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The potential therapeutic value of terpenes
Terpenes form part of a huge and diverse class of naturally occurring and volatile secondary metabolites produced by many plants, fruits, animals, insects, and other organisms. They are the largest group of naturally occurring metabolites, with over 55,000 types of terpenes produced by plants alone, primarily as essential oils. In humans, they contain significant biological properties such as antifungal, antiviral, antimicrobial, anti-inflammatory, antiparasitic, antihyperglycemic, anti-cancer, and analgesic agents. In plants, terpenes also play significant roles in defensive mechanisms against herbivores and invasive plants, disease resistance, chemical signaling and communication between plants, protection against photo-oxidation, plant-environment mediation, thermo-protection, and the attraction of pollinators. In addition, terpenes are responsible for a plant’s scent, taste, flavor, and pigmentation, leading to their commercial use as fragrances and food dyes. Terpenes are also used in the production of synthetic polymers, natural rubbers (polyisoprene), organic solvents, varnishes, inks, adhesives, cleaning products, biofuels, pesticides, and food and drink products. For these reasons, terpenes have significant value in modern medicine, pharmacy, nutraceuticals, cosmetics, and other industries.
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