在对健康成年人进行的两项随机交叉研究中,膳食中的无机磷酸盐添加剂和对 5 天膳食无机磷酸盐负荷的适应会改变急性钙稳态

IF 3.4 Q2 ENDOCRINOLOGY & METABOLISM JBMR Plus Pub Date : 2024-06-06 DOI:10.1093/jbmrpl/ziae075
M. Turner, Tom Mazzetti, Kathryn Neville, Emilie C. Ward, Jenny Munroe, Michael A. Adams, R. Holden
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引用次数: 0

摘要

含有无机磷酸盐添加剂的膳食中钙含量不均衡,这些膳食与骨代谢改变的发展有关。通过对健康人进行两项随机交叉研究,我们(1)描述了激素和尿液对两份报告含磷量相同(562-572 毫克)的膳食的反应,其中一份膳食使用了无机磷酸盐添加剂,且钙磷摩尔比相对较低(0.26 vs. 0.48);(2)与富含无机磷酸盐添加剂的膳食(约 1100 毫克磷/天)相比,评估 5 天暴露于推荐膳食磷量(约 700 毫克磷/天)后,急性稳态机制的适应情况。在每种饮食条件下,参与者在一夜禁食后口服 500 毫克无机磷酸盐形式的磷。测量项目包括血清钙、磷酸盐、PTH 和 FGF-23、维生素 D 代谢物以及尿钙和磷酸盐排泄量。与低添加剂的膳食相比,含有低 Ca:P 比的无机磷酸盐添加剂的膳食的血清磷酸盐含量更高,尿液中排出的磷酸盐也更多。虽然高添加剂膳食中的钙磷比和钙含量较低,但尿液中排出的钙量相同。随后,仅通过添加剂增加膳食磷酸盐会降低 24 小时的钙排泄量。尽管没有摄入钙,但口服磷酸盐挑战促进了尿钙的排泄,当预先适应高磷酸盐饮食后,尿钙的排泄会减少。这些数据表明,摄入无机磷酸盐会促进钙的排泄,但可能存在对膳食磷酸盐摄入量有反应的减少钙排泄的平衡机制。未来的研究需要评估富含无机磷酸盐添加剂的膳食对骨骼健康的潜在影响。
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Inorganic phosphate additives in meals and adaptations to 5 days of dietary inorganic phosphate loading alter acute calcium homeostasis in two randomized cross-over studies in healthy adults
Diets containing inorganic phosphate additives are unbalanced with respect to calcium and these diets have been linked to the development of altered bone metabolism. Using two randomized cross-over studies in healthy humans, we (1) characterized the hormonal and urinary response to two meals with the same reported phosphorus amount (562-572 mg), where one was manufactured with inorganic phosphate additives and a comparatively lower Ca:P molar ratio (0.26 vs. 0.48), and (2) assessed how acute homeostatic mechanisms adapt following 5-day exposure to recommended dietary phosphorus amount (~700 mg P/day) compared to a diet enriched with inorganic phosphate additives (~1100 mg P/day). Participants were then challenged with 500 mg of oral phosphorus in the form of inorganic phosphate after an overnight fast following each diet condition. Measurements included serum calcium, phosphate, PTH, and FGF-23, vitamin D metabolites, and urine calcium and phosphate excretion. Following the meal containing inorganic phosphate additives with a low Ca:P ratio, serum phosphate was higher and more phosphate was excreted in the urine compared to the low additive meal. Although the Ca:P and calcium content was lower in the high additive meal, the same amount of calcium was excreted into the urine. Subsequently increasing only dietary phosphate through additives resulted in lower 24-hour excretion of calcium. The oral phosphate challenge promoted urinary calcium excretion, despite no consumption of calcium, which was attenuated when pre-acclimated to a high phosphate diet. These data suggest that ingestion of inorganic phosphate promotes calcium excretion, but homeostatic mechanisms may exist to reduce calcium excretion that are responsive to dietary intake of phosphate. Future studies are required to evaluate potential implication of diets enriched with inorganic phosphate additives on bone health.
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来源期刊
JBMR Plus
JBMR Plus Medicine-Orthopedics and Sports Medicine
CiteScore
5.80
自引率
2.60%
发文量
103
审稿时长
8 weeks
期刊最新文献
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