COVID-19 对急性呼吸窘迫综合征患者住院后肺功能、心功能和肾功能以及长期生活质量的影响:后 COVID 巴西 3 研究方案

Fernando Luís Scolari, M. Rover, Geraldine Trott, Mariana Motta Dias da Silva, Denise de Souza, Raine Fogliati de Carli Schardosim, Rosa da Rosa Minho dos Santos, Emelyn de Souza Roldão, Duane Mocellin, Jennifer Menna Barreto de Souza, A. Miozzo, G. Rech, Carolina Rothmann Itaqui, Juliana de Mesquita, Gabriel Pozza Muller Estivalete, Hellen Jordan Martins Freitas, Catherine Vitória Pereira dos Santos, L. G. da Luz, Marcelo Kern, M. S. Marcolino, Bruna Brandão Barreto, Paulo R. Schwartzman, A. C. P. Antonio, Maicon Falavigna, C. Robinson, Carisi Anne Polanczy, R. G. Rosa
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引用次数: 0

摘要

ABSTRACT 理由:有关 COVID-19 引起的急性呼吸窘迫综合征住院后长期后遗症的证据仍然很少。目的:评估 COVID-19 引起的急性呼吸窘迫综合征住院后肺功能、心功能和肾功能以及生活质量的变化。方法:这将是一项多中心病例研究:这是一项多中心病例对照研究,共有 220 人参加。研究对象为因 COVID-19 导致的急性呼吸窘迫综合征而住院的患者。在对照组中,将选择在过去 12 个月中没有住院史或没有 COVID-19 长期症状的患者。所有患者都将接受肺活量测定和一氧化碳扩散测试、胸部断层扫描、心脏和肾脏钆磁共振成像、肌力测定、血清和尿肌酐、总蛋白、尿微量白蛋白尿以及生活质量问卷调查。患者将在出院后 12 个月接受评估,对照组将在纳入研究后 90 天内接受评估。所有统计分析均以 P < 0.05 为显著性阈值。研究结果研究的主要结果是 12 个月后测量的一氧化碳肺弥散能力。肺、心、肾功能的其他参数和生活质量是次要结果。结论本研究旨在确定巴西人群中因 COVID-19 引起的急性呼吸窘迫综合征住院患者的肺、心、肾功能长期后遗症和生活质量。
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Impact on pulmonary, cardiac, and renal function and long-term quality of life after hospitalization for acute respiratory distress syndrome due to COVID-19: Protocol of the Post-COVID Brazil 3 study
ABSTRACT Rationale: Evidence about long-term sequelae after hospitalization for acute respiratory distress syndrome due to COVID-19 is still scarce. Purpose: To evaluate changes in pulmonary, cardiac, and renal function and in quality of life after hospitalization for acute respiratory distress syndrome secondary to COVID-19. Methods: This will be a multicenter case–control study of 220 participants. Eligible are patients who are hospitalized for acute respiratory distress syndrome due to COVID-19. In the control group, individuals with no history of hospitalization in the last 12 months or long-term symptoms of COVID-19 will be selected. All individuals will be subjected to pulmonary spirometry with a carbon monoxide diffusion test, chest tomography, cardiac and renal magnetic resonance imaging with gadolinium, ergospirometry, serum and urinary creatinine, total protein, and urinary microalbuminuria, in addition to quality-of-life questionnaires. Patients will be evaluated 12 months after hospital discharge, and controls will be evaluated within 90 days of inclusion in the study. For all the statistical analyses, p < 0.05 is the threshold for significance. Results: The primary outcome of the study will be the pulmonary diffusing capacity for carbon monoxide measured after 12 months. The other parameters of pulmonary, cardiac, and renal function and quality of life are secondary outcomes. Conclusion: This study aims to determine the long-term sequelae of pulmonary, cardiac, and renal function and the quality of life of patients hospitalized for acute respiratory distress syndrome due to COVID-19 in the Brazilian population.
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