塞古尼亚南科罗丰巴医院发现的一例因慢性肺功能障碍而导致的古格罗-斯约格伦综合征(SGS)病例

C. D, D. M, Coulibaly, O, D. K, C. A, Sylla Mala, Keïta Kaly, S. Djibril, A. Koné, Drago, A. A, D. I, Kamissoko, C. O, M. A, D. M, G. H, D. Sow
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摘要

简介斯约格伦综合征(SS)是一种全身性自身免疫性疾病,其靶点是外分泌腺,尤其是唾液腺的上皮细胞。该病多发于女性,男女比例为 9:1,发病高峰在 50 岁左右。主要见于西方文献,似乎是仅次于 RA 的第二大疾病。在非洲,该病主要见于马格里布地区。我们报告了一例在塞古(Ségou)Nianankoro Fomba 医院发现的肺损伤病例。观察结果:患者 50 岁,无任何特殊的 ATCD,因慢性咳嗽伴粘液脓痰和呼吸困难就诊,病程已超过四(4)个月。尽管在肺病科进行的痰液 BARR 检测呈阴性,但抗结核治疗试验失败,因此她决定到内科就诊。临床检查显示,她患有 NYHA III 期呼吸困难。胸部 CT 的结论是双侧肺实质间质综合征伴有支气管扩张的炎症性支气管病。免疫学评估显示抗SSA和抗SSB抗体阳性。开始使用皮质类固醇和免疫抑制剂后,临床症状有所改善。结论:这一观察结果表明,在对顽固性咳嗽进行病因学评估时,寻找潜在的 SS 很有意义。
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A Case of Gougerot Sjögren Syndrome (SGS) Discovered by Chronic Pulmonary Impairment at the Nianankoro Fomba Hospital in Segou
Introduction: Sjögren's syndrome (SS) is a systemic autoimmune disease whose target is the epithelium of the exocrine glands and in particular the salivary glands. SS affects women more often with a sex ratio of 9 women to 1 man and the peak frequency is around age 50. It is mainly described in Western literature where it seems to come second after RA. In Africa, it is mainly reported in the Maghreb. We report a case, revealed by pulmonary damage at the Nianankoro Fomba hospital in Ségou. Observation: This was a patient, aged 50, without any particular ATCD, who had consulted for chronic cough with mucco-purulent sputum and dyspnea, which had been present for more than four (4) months. Faced with the failure of a trial anti-tuberculosis treatment despite the negativity of the sputum testing for BARR in the Pneumophthisiology department, she decided to consult internal medicine. Clinical examination revealed NYHA stage III dyspnea. A chest CT concluded with bilateral pulmonary parenchymal interstitial syndrome associated with inflammatory bronchopathy with bronchiectasis. The immunological assessment revealed positive anti–SSA and anti–SSB Abs. Clinical improvement was obtained after initiation of corticosteroids and immunosuppressants. Conclusion: This observation illustrates the interest of looking for latent SS in the etiological assessment of a persistent cough.
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