炎症性肠病患者围手术期营养注意事项

Barbara Bielawska
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引用次数: 0

摘要

尽管近几十年来炎症性肠病(IBD)的药物治疗取得了重大进展,但手术治疗在克罗恩病(CD)和溃疡性结肠炎(UC)中仍然很常见。虽然在生物制剂时代,UC 结肠切除术的风险有所下降,但大多数 CD 患者一生中至少要接受一次肠切除术。术前营养状况是手术发病率的一个既定决定因素。手术引起的代谢应激反应与手术损伤程度成正比。手术切口的愈合需要充足的瘦肉和微量元素储备,而且患者必须具备组织修复所需的新陈代谢能力。这一过程中任何一个环节出现问题都可能导致并发症,包括吻合失败、手术部位感染、胃肠道(GI)功能恢复延迟以及术后身体残疾和住院时间延长。
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Perioperative Nutritional Considerations In Patients With Inflammatory Bowel Disease
Despite significant advances in medical therapy for inflammatory bowel disease (IBD) in recent decades, surgical management remains common in the setting of both Crohn’s disease (CD) and ulcerative colitis (UC). While the risk of colectomy for UC has declined in the biologic era, most patients with CD will undergo at least one intestinal resection in their lifetime. Preoperative nutritional status is a wellestablished determinant of surgical morbidity. Surgery elicits a metabolic stress response that is proportional to the extent of surgical injury. Adequate lean body and micronutrient stores are needed for healing of surgical incisions, and the individual must be metabolically capable of anabolism for tissue repair. Deficits at any point in this process may lead to complications including anastomotic failure, surgical site infections, delayed return of gastrointestinal (GI) function, and postoperative physical disability with prolonged length of hospital stay.
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