精神疾病的连锁分析。2方法论的考虑。

Psychiatric developments Pub Date : 1985-01-01

N J Cox, B K Suarez

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引用次数: 0

摘要

分子生物学的最新进展使遗传连锁分析成为一种越来越有吸引力的工具，用于鉴定和表征与精神疾病病因有关的基因。然而，精神疾病的复杂性导致了许多方法上的困难，而不是在简单的孟德尔遗传特征的连锁分析中遇到的。前一篇文章综述了遗传连锁分析的基本概念。这篇论文的重点是方法上的困难与遗传连锁方法的应用精神疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Linkage analysis for psychiatric disorders. II. Methodological considerations.

Recent advances in molecular biology make genetic linkage analysis an increasingly attractive tool for the identification and characterization of genes involved in the etiology of psychiatric illnesses. However, the complex nature of psychiatric illnesses engenders a host of methodological difficulties not encountered in linkage analyses of simple, Mendelian genetic traits. A previous paper reviewed the basic concepts of genetic linkage analysis. This paper focuses on the methodological difficulties associated with the application of genetic linkage methods to psychiatric illnesses.

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Psychiatric developments

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