Anna Kasielska-Trojan , John T. Manning , Marek Kałuża , Ewa Głowacka , Bogusław Antoszewski
{"title":"怀孕头三个月母体性类固醇与母亲和儿童的数字比率","authors":"Anna Kasielska-Trojan , John T. Manning , Marek Kałuża , Ewa Głowacka , Bogusław Antoszewski","doi":"10.1016/j.earlhumdev.2024.106067","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>It is thought that digit ratios (2D:4D) are a correlate of 1st trimester maternal and foetal sex steroids. Here we consider the relationship of 2D:4D to the former.</p></div><div><h3>Method</h3><p>Digit lengths were directly measured with a calliper at infant age 13 months. Measures of T and E were obtained from mother's blood at 6–8 weeks, 10–11 weeks and 1st trimester means were calculated.</p></div><div><h3>Results</h3><p>There were 69 mother-infant pairs (33 boys). Sex differences in 2D:4D (boys<girls) and in maternal E and T (girls>boys) were found. For mothers of girls: there were negative relationships between 2D:4D and T at 6–8 weeks, 10–11 weeks and 1st trimester means. For infants: girls showed more correlations between 2D:4D and hormones than boys. For boys, there was one positive association between 2D:4D and E and two positive associations for E/T. For girls, 2D:4D was negatively related to T (four correlations) and positively related to E/T (four correlations). Considering associations in the total sample and controlling for sex, at 6–8 weeks right and left 2D:4D were positively related to E. At 10–11 weeks, right and left 2D:4D were negatively related to T. For 1st trimester means, 2D:4D's were positively related to E (right and left) and negatively related to T (right).</p></div><div><h3>Conclusion</h3><p>Infant 2D:4D was correlated with first trimester maternal sex steroids, particularly at 10–11 weeks. The correlations were negative for T, and positive for E and E/T with weaker effects for male infants. The latter pattern may arise because in boys T produced by foetal testes masks the effect of maternal T.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378378224001361/pdfft?md5=99a8bd2be205af92423f780a3d8a6c52&pid=1-s2.0-S0378378224001361-main.pdf","citationCount":"0","resultStr":"{\"title\":\"First trimester maternal sex steroids and the digit ratios of mothers and children\",\"authors\":\"Anna Kasielska-Trojan , John T. Manning , Marek Kałuża , Ewa Głowacka , Bogusław Antoszewski\",\"doi\":\"10.1016/j.earlhumdev.2024.106067\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>It is thought that digit ratios (2D:4D) are a correlate of 1st trimester maternal and foetal sex steroids. Here we consider the relationship of 2D:4D to the former.</p></div><div><h3>Method</h3><p>Digit lengths were directly measured with a calliper at infant age 13 months. Measures of T and E were obtained from mother's blood at 6–8 weeks, 10–11 weeks and 1st trimester means were calculated.</p></div><div><h3>Results</h3><p>There were 69 mother-infant pairs (33 boys). Sex differences in 2D:4D (boys<girls) and in maternal E and T (girls>boys) were found. For mothers of girls: there were negative relationships between 2D:4D and T at 6–8 weeks, 10–11 weeks and 1st trimester means. For infants: girls showed more correlations between 2D:4D and hormones than boys. For boys, there was one positive association between 2D:4D and E and two positive associations for E/T. For girls, 2D:4D was negatively related to T (four correlations) and positively related to E/T (four correlations). Considering associations in the total sample and controlling for sex, at 6–8 weeks right and left 2D:4D were positively related to E. At 10–11 weeks, right and left 2D:4D were negatively related to T. For 1st trimester means, 2D:4D's were positively related to E (right and left) and negatively related to T (right).</p></div><div><h3>Conclusion</h3><p>Infant 2D:4D was correlated with first trimester maternal sex steroids, particularly at 10–11 weeks. The correlations were negative for T, and positive for E and E/T with weaker effects for male infants. The latter pattern may arise because in boys T produced by foetal testes masks the effect of maternal T.</p></div>\",\"PeriodicalId\":11435,\"journal\":{\"name\":\"Early human development\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0378378224001361/pdfft?md5=99a8bd2be205af92423f780a3d8a6c52&pid=1-s2.0-S0378378224001361-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Early human development\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0378378224001361\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Early human development","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378378224001361","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景据认为，数字比（2D:4D）与怀孕头三个月的母体和胎儿的类固醇性别相关。我们在此探讨 2D:4D 与前者的关系。结果共有 69 对母婴（33 个男孩）。发现 2D：4D（男孩<女孩）以及母体 E 和 T（女孩>男孩）存在性别差异。对于女孩的母亲：在 6-8 周、10-11 周和妊娠头三个月的平均值中，2D:4D 和 T 之间呈负相关。对于婴儿：女孩的 2D:4D 与荷尔蒙之间的相关性高于男孩。对于男婴，2D:4D 和 E 之间有一个正相关，E/T 之间有两个正相关。对于女孩，2D:4D 与 T 呈负相关（四次相关），与 E/T 呈正相关（四次相关）。考虑到总样本中的相关性并控制性别，6-8 周时，右侧和左侧 2D:4D 与 E 呈正相关；10-11 周时，右侧和左侧 2D:4D 与 T 呈负相关。T呈负相关，E和E/T呈正相关，对男婴的影响较弱。出现后一种模式的原因可能是，在男婴中，胎儿睾丸产生的 T 会掩盖母体 T 的影响。
First trimester maternal sex steroids and the digit ratios of mothers and children
Background
It is thought that digit ratios (2D:4D) are a correlate of 1st trimester maternal and foetal sex steroids. Here we consider the relationship of 2D:4D to the former.
Method
Digit lengths were directly measured with a calliper at infant age 13 months. Measures of T and E were obtained from mother's blood at 6–8 weeks, 10–11 weeks and 1st trimester means were calculated.
Results
There were 69 mother-infant pairs (33 boys). Sex differences in 2D:4D (boys<girls) and in maternal E and T (girls>boys) were found. For mothers of girls: there were negative relationships between 2D:4D and T at 6–8 weeks, 10–11 weeks and 1st trimester means. For infants: girls showed more correlations between 2D:4D and hormones than boys. For boys, there was one positive association between 2D:4D and E and two positive associations for E/T. For girls, 2D:4D was negatively related to T (four correlations) and positively related to E/T (four correlations). Considering associations in the total sample and controlling for sex, at 6–8 weeks right and left 2D:4D were positively related to E. At 10–11 weeks, right and left 2D:4D were negatively related to T. For 1st trimester means, 2D:4D's were positively related to E (right and left) and negatively related to T (right).
Conclusion
Infant 2D:4D was correlated with first trimester maternal sex steroids, particularly at 10–11 weeks. The correlations were negative for T, and positive for E and E/T with weaker effects for male infants. The latter pattern may arise because in boys T produced by foetal testes masks the effect of maternal T.
期刊介绍：
Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival.
The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas:
Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
