Jian-Zi Liu, Yan-Duo Wang, Hui-Qi Fang, Gui-Bo Sun* and Gang Ding*,
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引用次数: 0
摘要
采用 UPLC-Q-TOF-MS/MS 方法，从真菌 Chaetomium cochliodes 中纯化了含有罕见笼环的 Chetocochliodin J (5) 和具有不寻常哌嗪-2,3-二酮环系的 Chetocochliodin K (6)，以及已知的类似物 chetomin (1)、chetoseminudin C (2)、chetocochliodin I (3) 和 oidioperazine E (4)。利用 HR-ESI-MS、NMR 和 ECD 光谱阐明了新化合物的结构。化合物 1、3 和 6 对 A549 和 HeLa 癌细胞株具有很强的细胞毒活性。
UPLC-Q-TOF-MS/MS-Based Targeted Discovery of Chetomin Analogues from Chaetomium cochliodes
Chetocochliodin M (5) containing a rare cage-ring and chetocochliodin N (6) featuring an unusual piperazine-2,3-dione ring system together with known analogues chetomin (1), chetoseminudin C (2), chetocochliodin I (3), and oidioperazine E (4) were targeted for purification from the fungus Chaetomium cochliodes using a UPLC-Q-TOF-MS/MS approach. The structures of the new compounds were elucidated using HR-ESI-MS, NMR, and ECD spectra. Compounds 1, 3, and 6 exhibited strong cytotoxic activities against A549 and HeLa cancer cell lines.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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