从心肌炎和炎症性心肌病的细胞景观变化中获得新见解。

IF 4.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Heart Failure Reviews Pub Date : 2024-09-01 Epub Date: 2024-06-19 DOI:10.1007/s10741-024-10406-w
Weiteng Wang, Hao Jia, Xiumeng Hua, Jiangping Song
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引用次数: 0

摘要

心肌炎和炎症性心肌病(ICM)的病因分类取得了进展,并已达成共识。然而,心肌炎/炎症性心肌病的发病机制仍不清楚,这影响了治疗的发展和疗效的改善。细胞转录和代谢重编程,以及心肌细胞与非心肌细胞(如免疫细胞)之间的相互作用,都是心肌炎/心肌病发生的原因。近年来,多组学技术,尤其是单细胞 RNA 测序技术的应用,使人们对疾病进展过程中发生的细胞景观变化有了更深入的了解。本文旨在全面概述有关心肌炎/心肌梗死的最新研究,尤其是单细胞测序所揭示的内容。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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New insights gained from cellular landscape changes in myocarditis and inflammatory cardiomyopathy.

Advances in the etiological classification of myocarditis and inflammatory cardiomyopathy (ICM) have reached a consensus. However, the mechanism of myocarditis/ICM remains unclear, which affects the development of treatment and the improvement of outcome. Cellular transcription and metabolic reprogramming, and the interactions between cardiomyocytes and non-cardiomyocytes, such as the immune cells, contribute to the process of myocarditis/ICM. Recent efforts have been made by multi-omics techniques, particularly in single-cell RNA sequencing, to gain a better understanding of the cellular landscape alteration occurring in disease during the progression. This article aims to provide a comprehensive overview of the latest studies in myocarditis/ICM, particularly as revealed by single-cell sequencing.

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来源期刊
Heart Failure Reviews
Heart Failure Reviews 医学-心血管系统
CiteScore
10.40
自引率
2.20%
发文量
90
审稿时长
6-12 weeks
期刊介绍: Heart Failure Reviews is an international journal which develops links between basic scientists and clinical investigators, creating a unique, interdisciplinary dialogue focused on heart failure, its pathogenesis and treatment. The journal accordingly publishes papers in both basic and clinical research fields. Topics covered include clinical and surgical approaches to therapy, basic pharmacology, biochemistry, molecular biology, pathology, and electrophysiology. The reviews are comprehensive, expanding the reader''s knowledge base and awareness of current research and new findings in this rapidly growing field of cardiovascular medicine. All reviews are thoroughly peer-reviewed before publication.
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